ID A0A3B4DWQ8_PYGNA Unreviewed; 1850 AA.
AC A0A3B4DWQ8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000027865.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000027865.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC Nav1.4/SCN4A subfamily. {ECO:0000256|ARBA:ARBA00038083}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR RefSeq; XP_017572858.1; XM_017717369.1.
DR RefSeq; XP_017572859.1; XM_017717370.1.
DR Ensembl; ENSPNAT00000001445.1; ENSPNAP00000027865.1; ENSPNAG00000013424.1.
DR GeneID; 108439134; -.
DR CTD; 564977; -.
DR GeneTree; ENSGT00940000167352; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 229..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 391..418
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 564..591
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 603..624
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 727..747
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 806..832
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1037..1055
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1076..1092
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1104..1124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1153..1179
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1277..1301
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1360..1378
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1390..1408
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1420..1440
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1477..1507
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1581..1604
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1621..1656
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 452..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1850 AA; 210597 MW; 5DA2270AF5DBA9C4 CRC64;
MARLLPHTDT DAFRRFTPET LVEIERRMAE EAAEQEHRKA LNIEIPEEDL PKPSKDLEAG
KALPFIYGDP PPELLNIPLE ELDPFYKAKK TFIVISKGNT INRFNAEPAC YILSPFSPIR
RGAIRILIHS LFSMFIMVTI LSNCVFMTMS NPPEWSKIME YVFTGIYTFE ALVKILSRGF
CMGDFTFLRD PWNWLDFMVI SMAYVTEFVD LGNVSALRTF RVLRALKTIT VIPGLKTIVG
ALIQSVKKLG DVMILTVFCL SVFALIGLQL FMGNLRHKCV LNPFRGLETS FNTTDNTTHT
NSTFDWEEYI NNQEHYYFLP DSLDALLCGN SSDSGRCPDG YVCMKAGRNP NYGYTSYDNF
GWAFLALFRL MTQDFWENLF QLTLRAAGKT YMIFFVVIIF LGSFYLINLI LAVVAMAYAE
QNEATIAEAK EKEEEYARIM EQLKKQAEQK KAMVKGSRTS LSSRKKGDDL ADDRLKTEHD
SIALKPLSDK GSLEILKSNG SKGSMDHLEV TSAHQRKPSA LSDESNAVDE LEDLERPCPP
FWYKFADIFL KWDCCTPWIR FKKWVYFIVM DPFVDLGITI CIILNTVFMA MEHYPMTPEF
ESVLSVGNLV FTGIFTAEMV LKLIAMDPYY YFQVGWNIFD SIIVTMSLVE LGLANVQGLS
VLRSFRLHSG ENEEFELQSA DVLIGHEEFG ESKPIGGLHT FVLMRVFKLA KSWPTLNMLI
KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ LFGKSYKDCV CKISADCELP RWHMTDFFHS
FLIVFRILCG EWIETMWDCM EVAGQGLCIV VFMMVMVIGN LVVLNLFLAL LLSSFSGDNL
ASDDDGEMNN LQIAIGRITR GIDWVKATVI RQVRRLLGLK PIEEQKKEND EDDLKTGNDL
VLNHMDSEDA AQMKKLGGTF ETALVPAVKV PIAKGESDFE SPNDDETSED EDKKADEKYK
LKNTEADDSS NCSTVDKPPE VEEAESEDEQ DLTTPEDCYT EKCIRRCPCL EVDITQGRGK
SWWNFRKTCF TIVEHNYFET FIIFMILLSS GALAFEDIYI EQRRVIKIIL EYADQVFTYV
FVVEMLLKWV AYGFKTYFTN AWCWLDFLIV DVSLISLTAN ILGYSELGPI KSLRTLRALR
PLRALSRFEG MRVVVNALVG AIPSIFNVML VCLIFWLIFS IMGVNLFAGK FYYCLNTTSE
ELFPLEDVNN KSDCFGHIAA GADARWMNLK VNYDNVGMGY LSLLQVATFK GWMDIMYAAV
DSRDVEDQPS YEANLYMYLY FVIFIIFGSF FTLNLFIGVI IDNFNQQKAK LGGQDLFMTE
EQKKYYNAMK KLGSKKPQKP IPRPQNCFQG FIFDIVTKQF FDILIMGLIC LNMITMMVET
DEQSEDMETI LYYINFVFIV MFTGECVLKI IALRQYYFSV GWNIFDFIVV ILSILGIMLA
DLIEKYFVSP TLFRVIRLAR IGRVLRLIRG AKGIRTLLFA LMMSLPALFN IGLLLFLIMF
IFSIFGMSNF AYVKKEMGID DMFNFETFGN SIICLFMITT SAGWDGLLSP ILNSSPPDCD
PEIENPGTDV RGNCGNPAVG IVFFCSYIVM SFLVVVNMYI AIILENFNVA TEESGEPLCE
DDFEMFYETW EKFDPDASQF IDYNSLSEFC DTLKDPLRIP KPNTIKLITM DLPMVPGDKI
HCLDILLALT TEVLGESEEM DTLKASMEEK FMANNPSKVS YEPITTTLRR KQEEVAAVVI
QRAYRKHMLR RTLKHASYMF REKSDLKRKD EEAPEKVGMI ASRLSQLYGD QASKQLPSVT
VAFPEKKNNV ARGEGKRPSV EVQNEVVLHS APFAVPESSA YVDNLRESIV
//
