ID   A0A3B4DXK1_PYGNA        Unreviewed;       912 AA.
AC   A0A3B4DXK1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H3 {ECO:0000256|ARBA:ARBA00039924};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000027786.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000027786.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: May act as a carrier of hyaluronan in serum or as a binding
CC       protein between hyaluronan and other matrix protein, including those on
CC       cell surfaces in tissues to regulate the localization, synthesis and
CC       degradation of hyaluronan which are essential to cells undergoing
CC       biological processes. {ECO:0000256|ARBA:ARBA00037051}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   AlphaFoldDB; A0A3B4DXK1; -.
DR   Ensembl; ENSPNAT00000001654.1; ENSPNAP00000027786.1; ENSPNAG00000013361.1.
DR   GeneTree; ENSGT00940000154554; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF115; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..912
FT                   /note="Inter-alpha-trypsin inhibitor heavy chain H3"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017292035"
FT   DOMAIN          29..158
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          318..501
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   912 AA;  102511 MW;  073E9277C910035D CRC64;
     MSTMWTVLLL CVSVYLCVPS RSYGAFIISR DVQQKRSVDS ALIEVQSVKI DCKVASRFAH
     TVMISTVLNK ANFSQEVFFE VELPKTAFIT NFSMEIDSKM YVGEVKEKEK AKKQYEKAVS
     SGQTAGLVKA SGRKMEKFSV SVNIAANSNV TFTLTYEELL QRRFGKYEIM IRVKPKQLVQ
     HFEIAADIYE PQGIAFLDYS AAFLTNELLP LVEKTVTDKK AHLSFSPTLD QQRKCPDCDG
     TLIDGYFYIN YDVNRVQDLG DIQVQFRIVS LQADVCEHNH LSSTTLLFSL ITVSVFQIVN
     GYFVHFFAPA DLQRLPKNVV FVIDRSGSMR GKKMEQTREA LLTILDDLYV EDHFGLISFD
     DKIVKWRPSL SKATKENVNA AKEFVKAITA VGWTNINDAV LHAVNILTAA KKNKTVPENS
     ASMIILLTDG DPTYGEKNLD TIKHNVQTAI GGNMSLFCLG FGFDVDYSFL DVMAKQNDGL
     ARRIYEASDA ILQLQGFYDE VASPLLSEVH FNYPEDKVNS LTGSYFKQLF NGSEIVIAGQ
     LNDIQMNDFA VEVSAQGAGN DFVVKGQASA QKWDTIFPDQ EYIFGDFTER LWAYLTIQQL
     LDKKDKGTPE EKANATAEAL ELSLKYNFVT PLTSMVVTKP ENEDKPEDAF IADKLTEDQR
     KFTGTSIPSQ TVPQTGTVPQ TSYSYASSPV NFGTIFNLVK DPLTGTVVNG QTIGDKKVDP
     ANKNNTYFGC FGIIHEKFGI RLMVSTQEIL VSEHGKQTKL FWSDNTSVKG LNMDLQVTKD
     RSLTVTLRNS VKFVIMLHKV WKKHPYHQDY LGFYTLDSHL FSQRVHGLLG QFYNGVQFEV
     SELFAGKDVD KLDAFMLVKG HRILVTRGWQ KDFRNDVKNG ENVPCWFIHN NGTGLIDGDL
     TDYIVSGLFK TN
//