ID   A0A3B4DXK3_PYGNA        Unreviewed;       996 AA.
AC   A0A3B4DXK3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Sorting nexin-14-like {ECO:0000313|Ensembl:ENSPNAP00000028208.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000028208.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000028208.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   AlphaFoldDB; A0A3B4DXK3; -.
DR   STRING; 42514.ENSPNAP00000028208; -.
DR   Ensembl; ENSPNAT00000000567.1; ENSPNAP00000028208.1; ENSPNAG00000013925.1.
DR   GeneTree; ENSGT00950000182856; -.
DR   OMA; YMFMQHI; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   GO; GO:0097352; P:autophagosome maturation; IEA:Ensembl.
DR   GO; GO:0021680; P:cerebellar Purkinje cell layer development; IEA:Ensembl.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        56..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          134..308
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          340..472
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          622..742
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   996 AA;  114730 MW;  B57013D97F959B3A CRC64;
     MLRSQMADVR TLLRSLRRGF KIDMLREVVR QYPVVCFFLM SMLSSTIILN RYLHILMIFW
     SFLAGAITFY CSLSPDHLVP NVLFSVKTRK KRPEQQELFP LGHSCAVCGK NKCTRHRPTL
     LLEKYQPWLG LKVHSKVDAS IGEVLELVLE NFVYPWYRDI TDDEACVDEV RQTFRFFASV
     LVRRAQKVDV PSVATGKMMK AAMKHIEIVA KAQQKVRNSE GLQQAALEEY GADLHVALRS
     RRDELNYLRK LTEMLFPYVM PPKATDCRSL ALLIREVMTG SVFLPTMDFM ADPDTVNHMV
     LIFIDDTPPE PATEPPSTLV PFLQKYADSR NKKPSVLKLD LKEIREQQDL LFRFMSFLKQ
     EGALHVLQFC LTVEEFNDKI LCPELSDSEM EQLHDEVQTI YKTYCLEESI DKISFDPFII
     EEIRSIAEGP YTGVVKLQQM CCLFEAYEHV LSLLENVFTP LFCHSDEYFR YLLCGAESPA
     RNAKLNRNLS LDDLSSDSTP PGWADNIISH RPLSINTKPP PSSGSPSIKS ILTLRPRILK
     SLPTSTKNTS KRGESFGISR IGSKLKGVFR STTMEGAMLP AYTMVDGDED MVEEATVVVE
     DESPVPLDVV SNLGTQRNLS AWTIAIPFVD FYEDEAKKER VPVFCIDVER HDRQHASHEL
     ETWSIYRRYL EFYVLESKLT EFHGSFQDAQ LPSKRIIGPK NYEFLNSKRG EFEEYLQNLL
     RHPELSNSQL LADFLSPYGM ETQFLDKMLP DVNLGRIFKS VPGKLIKEKG QNLEPFLQSF
     FGSCESPKPK PSRPELTVLS PTAGNKKLLN ELYKNNANQP DSMDRRQNQN YFMEVMDLEG
     VYDYMMYVGR MVFRMPDWLH HVLCGGRILF KRTLEAYMDN YLQSKLDKIL QEHRVVSLIT
     LLRDAVFCEN NEERSPEDKQ RRAKQTFEEM MNYLPDIVGK CIGEENKSEG IQLLFSCIQQ
     PLLNKQMTYV LLDIAVQELF PELHSSTKED PSSRRM
//