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Database: UniProt
Entry: A0A3B4DXM6_PYGNA
LinkDB: A0A3B4DXM6_PYGNA
Original site: A0A3B4DXM6_PYGNA 
ID   A0A3B4DXM6_PYGNA        Unreviewed;      1217 AA.
AC   A0A3B4DXM6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000027749.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000027749.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Central component of cohesin, a complex required for
CC       chromosome cohesion during the cell cycle. The cohesin complex may form
CC       a large proteinaceous ring within which sister chromatids can be
CC       trapped. At anaphase, the complex is cleaved and dissociates from
CC       chromatin, allowing sister chromatids to segregate. Cohesion is coupled
CC       to DNA replication and is involved in DNA repair. The cohesin complex
CC       also plays an important role in spindle pole assembly during mitosis
CC       and in chromosomes movement. {ECO:0000256|ARBA:ARBA00034085}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere
CC       {ECO:0000256|ARBA:ARBA00004584}. Nucleus
CC       {ECO:0000256|PIRNR:PIRNR005719}.
CC   -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC       {ECO:0000256|ARBA:ARBA00005917}.
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DR   RefSeq; XP_017541770.1; XM_017686281.1.
DR   AlphaFoldDB; A0A3B4DXM6; -.
DR   STRING; 42514.ENSPNAP00000027749; -.
DR   Ensembl; ENSPNAT00000001752.1; ENSPNAP00000027749.1; ENSPNAG00000007202.1.
DR   GeneID; 108413659; -.
DR   CTD; 9126; -.
DR   GeneTree; ENSGT00580000081628; -.
DR   OMA; DQHQSMR; -.
DR   OrthoDB; 231904at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   CDD; cd03272; ABC_SMC3_euk; 1.
DR   Gene3D; 1.20.1060.20; -; 1.
DR   Gene3D; 3.30.70.1620; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   InterPro; IPR024704; SMC.
DR   InterPro; IPR041741; SMC3_ABC_euk.
DR   InterPro; IPR010935; SMC_hinge.
DR   InterPro; IPR036277; SMC_hinge_sf.
DR   PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR   PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR   Pfam; PF06470; SMC_hinge; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   PIRSF; PIRSF005719; SMC; 2.
DR   SMART; SM00968; SMC_hinge; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF75553; Smc hinge domain; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005719}.
FT   DOMAIN          530..643
FT                   /note="SMC hinge"
FT                   /evidence="ECO:0000259|SMART:SM00968"
FT   REGION          243..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1060..1089
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          399..503
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          675..853
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          962..989
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1217 AA;  141515 MW;  6E0A8E5CADE408BB CRC64;
     MYIKQVIIQG FRSYRDQTVV DPFSSKHNVI VGRNGSGKSN FFYAIQFVLS DEFSHLRPEQ
     RLALLHEGTG PRVISAFVEI IFDNSDNRLP IDKEEVSLRR VIGAKKDQYF LDKKMVTKND
     VMNLLESAGF SRSNPYYIVK QGKINQMATA PDSQRLKLLR EVAGTRVYDE RKEESISLMK
     ETEGKREKIN ELLKYIEERL HTLEDEKEEL AQYQKWDKMR RALEYTIYNQ ELNETRAKLD
     ELSSKRETCG DKSRQLRDAQ QDARDKVEET ERVVRELKAR ISAMKEEKEQ LSAERQEQIK
     QRTKLELKAK DLQDELAGNS EQRKRLLKER QKLLEKIEEK QKELQETEPK FNTVKEKEER
     GISRLAQATQ ERTDLYAKQG RGSQFTSKEE RDKWIKKELK SLDQAINDKK RQIAAIHKDL
     EDTEANKEKN LEQYNKLDQD LNEVKTRVEE LDKKYYEVKN RKDELQSERN YLWREENAEQ
     QALAAKREDL EKKQQLLRAA TGKAILNGID SINKVLEHFR RKGINQHVIN GYHGIVMNNF
     ECEPAFYTCV EVTAGTRLFY HIVETDEVST KILMEFNKMN LPGEVTFLPL SKLDVRDTAY
     PETNDAIPMI SKLRYSPNFD KAFKHVFGKT LICRSMEVST QLARAFTMDC ITLEGDQVSH
     RGALTGGYYD TRKSRLELQK DMRKAEEELA ELEAKLNENL RRNIERINNE IDQLMNQMQQ
     IETQQRKFKA SRDSILSEMK MLKEKRQQSE KTFMPKQRSL QSLEASLHAM ESTRESLKAE
     LGTDLLSQLS LEDQRRVDDL NDEIRQLQQD NRQLLNERIK LEGIMTRVET YLNENLRKRL
     DQVEQELNEL RETEGGTVLT ATTSELDGIN KRIKDTMARS EDLDSLIDKT EIEIKDHIKS
     MDRWKTIEKE QNDAINHDTK ELEKMTNRQG MLLKKKEECM KKIRELGSLP QEAFEKYQTL
     TLKQLFRKLE QCNTELKKYS HVNKKALDQF VNFSEQKEKL IKRQDELDRG YKSIMELMNV
     LELRKYEAIQ LTFKQVSKNF SEVFQKLVPG GKATLVMKKG DAEGGQSQDE GEGGTDSERG
     SASQSSVPSV DQFTGVGIRV SFTGKQGEMR EMQQLSGGQK SLVALALIFA IQKCDPAPFY
     LFDEIDQALD AQHRKAVSDM IVELAGHAQF ITTTFRPELL ESADKFYGVK FRNKVSHIDV
     ISAEQAKDFV EDDTTHG
//
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