ID   A0A3B4DYN7_PYGNA        Unreviewed;       906 AA.
AC   A0A3B4DYN7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Solute carrier family 12 member 9 {ECO:0000256|ARBA:ARBA00019359};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000028119.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000028119.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   RefSeq; XP_017555925.1; XM_017700436.1.
DR   RefSeq; XP_017555933.1; XM_017700444.1.
DR   AlphaFoldDB; A0A3B4DYN7; -.
DR   STRING; 42514.ENSPNAP00000028119; -.
DR   Ensembl; ENSPNAT00000000832.1; ENSPNAP00000028119.1; ENSPNAG00000013682.1.
DR   GeneID; 108429000; -.
DR   CTD; 56996; -.
DR   GeneTree; ENSGT00940000159400; -.
DR   OMA; VANVFSC; -.
DR   OrthoDB; 5490251at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF98; SOLUTE CARRIER FAMILY 12 MEMBER 9; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        124..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        301..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        345..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        427..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        466..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          47..539
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          550..638
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
SQ   SEQUENCE   906 AA;  98795 MW;  5229761027B13913 CRC64;
     MACERSPLLA HGIFSMVADN GDSRRGSSAA GDSSSKANPR TLNTFFGVIV PTILSMFSII
     IFLRTGFVIG HAGLLYGLLM LGVAYFIISL TILSICAIST NGAVQGGGAY FMISRSLGPE
     FGGSIGLMFF LAKVCACGVY VLGLVEAILN IFGQDAAVGM AQGIRVLPQG YWFSVLYSSV
     LLLLCLVVCL VGAHIYAKAS FITLIVVTVA VLSILISPLI VGPRHFNLTH MLDHNHTIIH
     GVYTGFNSST LANNLGPGYS LDYSTNKMMS FSAVFAVLFT SCTGIMAGAN MSGELKNPSV
     AIPKGTIIAV LYAFVVYVLL FLLLSSTCDR LFLINDYAVF QRINIWPPFV IVGVYCASLS
     AAMCSLIGAS RILHALAVDQ LFGLPLAPAA ITSSSGNPWV SVLYTWVLVQ CTLFAGQLNV
     IAELVTVFYL LAYAAVDLAC LALEWASAPN FRPTFQLFSW HTCLLGMLSC LVMMFVINAV
     YSSASIVMLL LLLLFLHYRS PTSSWGYISQ ALIFHQVRKY LLMLDSRKDH VKFWRPQVLL
     MVSNPRSSCQ LISFVNQLKK GGLFILGHVQ LGDLDMLPTD PVQQHYNFWL SLVDKLDVKA
     FVDLTLSPSV RQGTQHLLRI TGLGGMKPNT LVLGFYDNCY PEDYFLQEAA FCEGADKGSG
     SSAGFEGDHF GVDLPSLQAH FPPVRHTESP RFLQPDEYVG IISDAIKMGK NVCLARYFFQ
     LPPEGKGTSA KYGDSSDMID VWPSNLLSAD GSGSFADVCS LFLLQMACIL NMATRWRRAR
     VRIFLCVEAE SGDQGWLAKE ERFRELLGKL RIRATIKIVA WDRVVRLLRG TDSTAPPVAS
     EEFLSAVNSL LKEHSTSAAV RFLYLPRPPT NSGQSQQYLA QLDAVTQGLG PTLLIHGLTP
     VTCTEL
//