ID   A0A3B4E0J1_PYGNA        Unreviewed;       556 AA.
AC   A0A3B4E0J1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Sodium/potassium/calcium exchanger 4-like {ECO:0000313|Ensembl:ENSPNAP00000029228.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000029228.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000029228.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in)
CC         + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:29103, ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00033627};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. SLC24A subfamily. {ECO:0000256|ARBA:ARBA00005364}.
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DR   AlphaFoldDB; A0A3B4E0J1; -.
DR   STRING; 42514.ENSPNAP00000029228; -.
DR   Ensembl; ENSPNAT00000016129.1; ENSPNAP00000029228.1; ENSPNAG00000015165.1.
DR   GeneTree; ENSGT01030000234532; -.
DR   OMA; CACGDEE; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0120199; C:cone photoreceptor outer segment; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR   InterPro; IPR004481; K/Na/Ca-exchanger.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR   PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR   PANTHER; PTHR10846:SF21; SODIUM_POTASSIUM_CALCIUM EXCHANGER 4; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Calcium {ECO:0000256|ARBA:ARBA00022568};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT   TRANSMEM        27..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        208..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        232..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        421..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        455..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        498..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        525..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          109..250
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   DOMAIN          422..550
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
SQ   SEQUENCE   556 AA;  61460 MW;  1CBDB7F184F641E1 CRC64;
     MESEQSSSLS KKSALARLFR ARKRREMLFV QVCFVCSVLL AAWCMSAVLS RSGHGIVLQE
     TPHTGRRLMA MEDDNETEEK NCSDPAIHEF PADIFTNRER TRGAVLLHIF AAVYMFLALA
     IVCDDYFVTS LEKICEKLHL SEDVAGATFM AAGSSAPELF ASVIGVFITH GDVGVGTIVG
     SAVFNILCII GVCGIFAGQV VHLTKFSVFR DSFYYTLSVV ALIAFIYDGR IVWWESLVLM
     VMYIGYIIIM KFNTSMQNYF AGKDDKGIAN GNAMISELED VKPSKMYTRG SVVMVDEMMN
     SSPPNYRFPE AGLRVMITNH FGPKTRLRMA SRLIIHEQQR LMQASNGVDS TLVVDGKADT
     LENGNMPEDK LTEDEENELS SPFVIPGGAM NRLKFIISWP ILALLYFTIP NCGKPRWEKF
     FMLSFFLSTL WIAVFSYFMV WMVTIIGYTL GIPDVIMGIT FLAAGTSVPD CIASLIVARQ
     GLGDMAVSNT IGSNVFDILV GLGIPWGIQT MAVNYGSVVK INSRGLLYSV VLLLGSVALT
     VSYSILSNMN YKQGLH
//