ID A0A3B4E4G1_PYGNA Unreviewed; 1168 AA.
AC A0A3B4E4G1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Metabotropic glutamate receptor 5-like {ECO:0000313|Ensembl:ENSPNAP00000030640.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000030640.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000030640.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3B4E4G1; -.
DR Ensembl; ENSPNAT00000036264.1; ENSPNAP00000030640.1; ENSPNAG00000017514.1.
DR GeneTree; ENSGT01030000234595; -.
DR OMA; TYVPEHP; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:UniProt.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR CDD; cd15450; 7tmC_mGluR5; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000202; GPCR_3_mGluR5.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR019588; Metabotropic_Glu_rcpt_Homer-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF165; METABOTROPIC GLUTAMATE RECEPTOR 5A; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF10606; GluR_Homer-bdg; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01055; MTABOTROPC5R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SMART; SM01229; GluR_Homer-bdg; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1168
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017245960"
FT TRANSMEM 589..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 748..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 587..849
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 1119..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1168 AA; 129682 MW; A1B0EFEADB46132F CRC64;
MGVLLFLLFT LLGDDTRPVS LGALVQAQSN ERRVLAHIPG DIIIGALFSV HHQPPADKVH
ERKCGAVREQ YGIQRVEAMM HTLDRINADP DILPNITLGC EIRDSCWHSA VALEQSIEFI
RDTLVSAEEE ESMSKCAADG GGMPMRGKKP IVGLIGPGSS SVAIQVQNLL QLFNIPQIAY
SATSMDLSDK SLYKYFMRVV PSDAQQARAM VDIVKRYNWT YVSAIHTEGN YGESGMEAFK
DMAAKEGICI AHSDKIYSNA GEQSFDRLLE KLRSHLPKAR VVACFCEGMT VRGILMAMRR
RRLVGEFLLV GSDGWADRYD VTDGYQREAA GGITIKLQSA YVTWFDDYYL NLQPDTNQRN
PWFPEFWQHR FQCRLKGHPQ ENPKYNRTCT KKESLRLHYA QDTKMGFVIN AIYSMAYGLH
AMQKSLCPGY KGLCEAMRPI DGRKLLEFLM RTNFTGVSGE VVLFDENGDS PGRYEIMNFK
QMSEEDYSYI HVGSWDNRGL KMDDEEIWAN SSAIIHSVCS DPCEKAQIKV IRKGEVSCCW
TCTPCKENEY VFDEYTCRAC ELGSWPTDDL TGCEPIPVHY LQWGDPEPIA AVVFACLGLL
ATIFVMLIFV RFHDTPVVKS SSRELCFIIL AGICLGYLCT FCLIAKPHVV YCYLQRLGIG
LSPAMSYSAL VTKTNRIARI LAGSKKKICT KKPRFMSACA QLVIAFILIF LQLAIIVALF
IMEPPQVIYD YPSIREVHLI CNTTTLGVVA PLGYNGLLIL SCTFYAFKTR NVPANFNEAK
YIAFTMYTTC IIWLAFVPIY FGSNYKIITM CFSVSLSATT ALCCMFAPKV YIMLAKPERN
VRSAFTTSTV VRMHVGDGKS ASAASRSSSL ANLWRRRGSG TDNSTFSFRS SNGKTVTWAQ
NERGYRPNLW KRISIHIKKK EESNQTAIIK PFSKGCDAPP DTGVKLSYDR PQSAQRYPVT
YRPRTPSPLP TVCQRGSIQR FVALPSYLTE RSQRAGPQQT SIMDQITSVV NRFTANISEL
NSMMLPASPP PGTSINVPGP SSPTFRLLSR DIPQLSTTVT TYAEVVAAAN ATPRSAVGIT
GGIITGGSSR ASPASLSDSI YDSSSAVRTT ELEELAALTP PSPFRDSSVG SASDSPTSPD
SELALCQPCS PKYDRLMLRN YSQSSSSL
//
