ID   A0A3B4E4R3_PYGNA        Unreviewed;       725 AA.
AC   A0A3B4E4R3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=CCR4-NOT transcription complex subunit 3 {ECO:0000313|Ensembl:ENSPNAP00000030750.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000030750.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000030750.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR005290}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005290}.
CC   -!- SIMILARITY: Belongs to the CNOT2/3/5 family.
CC       {ECO:0000256|ARBA:ARBA00007682, ECO:0000256|PIRNR:PIRNR005290}.
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DR   AlphaFoldDB; A0A3B4E4R3; -.
DR   Ensembl; ENSPNAT00000036309.1; ENSPNAP00000030750.1; ENSPNAG00000017679.1.
DR   GeneTree; ENSGT00390000014743; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0030015; C:CCR4-NOT core complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-UniRule.
DR   GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:2000036; P:regulation of stem cell population maintenance; IEA:UniProt.
DR   Gene3D; 2.30.30.1020; CCR4-NOT complex subunit 2/3/5, C-terminal domain; 1.
DR   InterPro; IPR038635; CCR4-NOT_su2/3/5_C_sf.
DR   InterPro; IPR012270; CCR4-NOT_su3/5.
DR   InterPro; IPR040168; Not2/3/5.
DR   InterPro; IPR007282; NOT2/3/5_C.
DR   InterPro; IPR007207; Not_N.
DR   PANTHER; PTHR23326; CCR4 NOT-RELATED; 1.
DR   PANTHER; PTHR23326:SF1; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3; 1.
DR   Pfam; PF04153; NOT2_3_5_C; 1.
DR   Pfam; PF04065; Not3; 1.
DR   PIRSF; PIRSF005290; NOT_su_3_5; 2.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005290};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005290};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|PIRNR:PIRNR005290};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR005290};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PIRNR:PIRNR005290}.
FT   DOMAIN          4..232
FT                   /note="CCR4-Not complex component Not N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04065"
FT   DOMAIN          594..719
FT                   /note="NOT2/NOT3/NOT5 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04153"
FT   REGION          245..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          366..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..286
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..308
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..396
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   725 AA;  78111 MW;  514038719E462E07 CRC64;
     MADKRKLQGE IDRCLKKVAE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK EIKKLQRLRD
     QIKTWVASNE IKDKRQLVEN RKLIETQMER FKVVERETKT KAYSKEGLGL AQKVDPAQKE
     KEETEQWLTN TIDTLNMQVD QFESEVESLS VQTRKKKGDK EKQDRIEELK RLIERHRYHI
     RMLETILRML DNDSVQVEAI HKIKDDVEYY IDSSQDPDFE ENEFIYDDLD LEDIRKSLCS
     GVRAGVSSPG PENLPPFTLS SSSGPSNNAP SPPSHPNLPT PTTPSLPSSS TPGLATSSSQ
     SQASTVLSTG GSGLNLGLGL SLVKGGVTVT SSSNSSSVAQ MSGLGLAGMP SSHSTMAGLL
     SGSTPAPYAQ AAAGGTTSSA PGGPVGNSSS SGSAAVAVGG TGVSSGAPTN GTSAGAGLGL
     LGSSPGHGGL SGGILSLVPG QTPLQGPTQV PMSPVGTVPG GSAGVGVSGG NGSSAAPGGG
     VGGNMAPARP PSVVKQNGGT SLMLPLQAPE PLSSLKAMAE RAALGSGLDG EIPSLHLTDR
     DLFSGTSATP GPPAAPQPAV TEVNLPPSLG ACPLGPTPLS KDQLYQQAMQ EAAWTHMPHP
     SDSERIRQYL MRNPCPTPPF HHQMPPHHSD SIEFYQRLST ETLFFIFYYL EGTKAQYLSA
     KALKKQSWRF HTKYMMWFQR HEEPKTITDE FEQGTYIYFD YEKWGQRKKE GFTFEYRYLE
     DRDLQ
//