ID   A0A3B4E516_PYGNA        Unreviewed;       851 AA.
AC   A0A3B4E516;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSPNAP00000030855.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000030855.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000030855.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B4E516; -.
DR   Ensembl; ENSPNAT00000019304.1; ENSPNAP00000030855.1; ENSPNAG00000018222.1.
DR   GeneTree; ENSGT00940000163991; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061:SF528; C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED; 1.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01535; VOMERONASL2R.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        582..605
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        620..640
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        652..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        696..715
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        741..764
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        776..796
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        808..832
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          582..846
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   851 AA;  94798 MW;  AEBECB280F6C82BD CRC64;
     MAFPISLELK ELFCRLWTDA QLPGLSMYGD FIIGGIFAIH YYTRSEQNTY TRQPLQPQCS
     GSMDFRELRF ARAMEFTIQE INNRTDLLPG ITLGYQIYDS CSAVSMSVKA TFQFANGMDP
     FFNETDSCSK SAAAAVPALV GDSTSTTSIS MARQLGLFGI PQVSHYATCA CLSDKRQYPA
     FLRTIPSDHH QAAALARMVK HFGWTWIGAV RSDTDYGNYG MASFLKAAQE EGICVEYSES
     YYRTQPRSKL ERVANVIRRS TARVIVAFVN SGDMRFLLEE LARQPPPPMQ WIGSETWITD
     PDFLRFNMCA GAIGFGVPRS VIPGLREFLL DLSPAQALKS PLLTEFWESS FSCSLKGSSE
     GARGCNGSED IRALQNPYTD TSQLRITNLV YKATYAIAHA IHGLCTPGLD EGCEMCSVSI
     NVLLIYFLFN HIPLQILNQL KRVNITTKNG YQVLFDSSGD PVAVYELINW QVKKDGSLEF
     VTVGHYDSSR PRGQEFSMSR AISWMGQQRE VPRSVCSESC PPGTRKAVQK GRPVCCYDCI
     PCAEGEINSL DCLRCPPEFW PNVQRDSCLP KPVEFLSWDD TLSVILTAFS ITGAFIAVCV
     AAVFYKHKTS PIVRANNSEL SFLLLFSLTL CFLCSLTFIG RPSEWSCMLR HTAFGITFVL
     CISCVLGKTI VVLMAFRATL PGSNAMKWFG PPQQRLSVLA FTFIQALICV IWLKISPPLP
     LKNLKHYKER IILECGLGSA IGFWAVLGYI GFLALLCFIL AFLARKLPDN FNEAKFITFS
     MLIFCAVWIT FIPAYVSSPG KFTVAVEIFA ILASSFGLII CIFAPKCFII VFRPEQNTKK
     HIMGKVPSKA L
//