ID A0A3B4E5D3_PYGNA Unreviewed; 700 AA.
AC A0A3B4E5D3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
GN Name=MTRR {ECO:0000313|Ensembl:ENSPNAP00000030536.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000030536.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000030536.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR RefSeq; XP_017573758.1; XM_017718269.1.
DR AlphaFoldDB; A0A3B4E5D3; -.
DR STRING; 42514.ENSPNAP00000030536; -.
DR Ensembl; ENSPNAT00000036205.1; ENSPNAP00000030536.1; ENSPNAG00000017312.1.
DR GeneID; 108439714; -.
DR CTD; 4552; -.
DR GeneTree; ENSGT00940000155822; -.
DR OMA; RKGICTG; -.
DR OrthoDB; 276396at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd06203; methionine_synthase_red; 1.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 9..152
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 275..538
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 700 AA; 78271 MW; 8361E2BCDE88FB16 CRC64;
MPCGVASQFL ILYGSQRGQA QSIAEEICEQ AAEHGFVADI SCVSKGEKYN LERERGPVVF
VVSTTGDGEP PDTALKFVKK IKNKSLPCDH YSHLHYALLA LGDTNYANFC NCGKTIDSRL
QELGAKHFYA TGHADDGTGL EIVVDPWIEG LWEALKKTFA KMSASNQEGT NQGEVTKKSI
QQEAQIQEKL DSSAISLSLL KLTDVETEKG KAETSVLESK STDILGAPLE ASLIRSVPPL
SGSSLNVPAL PPSYLDVCLE DSPAEEESAH HVVKEGFYEV AVSGAAHLTR DDAVKSAILL
ELDISDQDMP YQPGDAFDVL CLNRASEVEE LLRRLGLKDQ RSQSVHLQLR KDTKKKGAQV
PSYIPQKCSL EYLLTWCLEI RSTPKKAFVR ALVDWTQDSR EKRRLQELCS REGSADYNRF
VRDTNLCLLD LLQAFKSCSP PLSLVIEHLP KLQPRAYSAA SSSLRHPGKV HFVFSVVDFP
ACVEHPERTG LCTGWLMHHV SAILQPYGKT ASAEKTADCP ALPKINVRPR VSNTFHLPSD
PSAPIVMVGP GTGVAPFIGF LQQRYQERVE KQDDVFGETW LFFGCRHKDR DFIFREELER
FVENGTLNHL KVSFSREELD GNEPRYVQHL LLLHAKNMVH VLFKENGYFY VCGDAKNMAK
DVNDALIEMI TKELQLDKLE SMKMVAKLRE EKRYLQDIWS
//