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Database: UniProt
Entry: A0A3B4E5D3_PYGNA
LinkDB: A0A3B4E5D3_PYGNA
Original site: A0A3B4E5D3_PYGNA 
ID   A0A3B4E5D3_PYGNA        Unreviewed;       700 AA.
AC   A0A3B4E5D3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE            EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
GN   Name=MTRR {ECO:0000313|Ensembl:ENSPNAP00000030536.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000030536.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000030536.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR   RefSeq; XP_017573758.1; XM_017718269.1.
DR   AlphaFoldDB; A0A3B4E5D3; -.
DR   STRING; 42514.ENSPNAP00000030536; -.
DR   Ensembl; ENSPNAT00000036205.1; ENSPNAP00000030536.1; ENSPNAG00000017312.1.
DR   GeneID; 108439714; -.
DR   CTD; 4552; -.
DR   GeneTree; ENSGT00940000155822; -.
DR   OMA; RKGICTG; -.
DR   OrthoDB; 276396at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd06203; methionine_synthase_red; 1.
DR   Gene3D; 3.40.50.360; -; 1.
DR   Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 1.
DR   InterPro; IPR003097; CysJ-like_FAD-binding.
DR   InterPro; IPR017927; FAD-bd_FR_type.
DR   InterPro; IPR001094; Flavdoxin-like.
DR   InterPro; IPR008254; Flavodoxin/NO_synth.
DR   InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR   InterPro; IPR029039; Flavoprotein-like_sf.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR   InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR   PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR   Pfam; PF00667; FAD_binding_1; 1.
DR   Pfam; PF00258; Flavodoxin_1; 1.
DR   Pfam; PF00175; NAD_binding_1; 1.
DR   PRINTS; PR00369; FLAVODOXIN.
DR   PRINTS; PR00371; FPNCR.
DR   SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR   SUPFAM; SSF52218; Flavoproteins; 1.
DR   SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   FMN {ECO:0000256|ARBA:ARBA00022643};
KW   Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          9..152
FT                   /note="Flavodoxin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50902"
FT   DOMAIN          275..538
FT                   /note="FAD-binding FR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51384"
SQ   SEQUENCE   700 AA;  78271 MW;  8361E2BCDE88FB16 CRC64;
     MPCGVASQFL ILYGSQRGQA QSIAEEICEQ AAEHGFVADI SCVSKGEKYN LERERGPVVF
     VVSTTGDGEP PDTALKFVKK IKNKSLPCDH YSHLHYALLA LGDTNYANFC NCGKTIDSRL
     QELGAKHFYA TGHADDGTGL EIVVDPWIEG LWEALKKTFA KMSASNQEGT NQGEVTKKSI
     QQEAQIQEKL DSSAISLSLL KLTDVETEKG KAETSVLESK STDILGAPLE ASLIRSVPPL
     SGSSLNVPAL PPSYLDVCLE DSPAEEESAH HVVKEGFYEV AVSGAAHLTR DDAVKSAILL
     ELDISDQDMP YQPGDAFDVL CLNRASEVEE LLRRLGLKDQ RSQSVHLQLR KDTKKKGAQV
     PSYIPQKCSL EYLLTWCLEI RSTPKKAFVR ALVDWTQDSR EKRRLQELCS REGSADYNRF
     VRDTNLCLLD LLQAFKSCSP PLSLVIEHLP KLQPRAYSAA SSSLRHPGKV HFVFSVVDFP
     ACVEHPERTG LCTGWLMHHV SAILQPYGKT ASAEKTADCP ALPKINVRPR VSNTFHLPSD
     PSAPIVMVGP GTGVAPFIGF LQQRYQERVE KQDDVFGETW LFFGCRHKDR DFIFREELER
     FVENGTLNHL KVSFSREELD GNEPRYVQHL LLLHAKNMVH VLFKENGYFY VCGDAKNMAK
     DVNDALIEMI TKELQLDKLE SMKMVAKLRE EKRYLQDIWS
//
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