ID A0A3B4E828_PYGNA Unreviewed; 420 AA.
AC A0A3B4E828;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Pannexin {ECO:0000256|RuleBase:RU010713};
GN Name=PANX {ECO:0000256|RuleBase:RU010713};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000031838.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000031838.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Structural component of the gap junctions and the
CC hemichannels. {ECO:0000256|RuleBase:RU010713}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- PTM: S-nitrosylation inhibits channel currents and ATP release.
CC {ECO:0000256|PIRSR:PIRSR600990-50}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
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DR RefSeq; XP_017554753.1; XM_017699264.1.
DR AlphaFoldDB; A0A3B4E828; -.
DR STRING; 42514.ENSPNAP00000031838; -.
DR GlyCosmos; A0A3B4E828; 2 sites, No reported glycans.
DR Ensembl; ENSPNAT00000021186.1; ENSPNAP00000031838.1; ENSPNAG00000019410.1.
DR GeneID; 108428339; -.
DR CTD; 393890; -.
DR GeneTree; ENSGT00940000153972; -.
DR OMA; IPDRFQC; -.
DR OrthoDB; 2996841at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR GO; GO:0006812; P:monoatomic cation transport; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0032732; P:positive regulation of interleukin-1 production; IEA:InterPro.
DR InterPro; IPR000990; Innexin.
DR InterPro; IPR039099; Pannexin.
DR PANTHER; PTHR15759; PANNEXIN; 1.
DR PANTHER; PTHR15759:SF5; PANNEXIN-1; 1.
DR Pfam; PF00876; Innexin; 1.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|RuleBase:RU010713};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Glycoprotein {ECO:0000256|PIRSR:PIRSR600990-51};
KW Ion channel {ECO:0000256|RuleBase:RU010713};
KW Ion transport {ECO:0000256|RuleBase:RU010713};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; S-nitrosylation {ECO:0000256|PIRSR:PIRSR600990-50};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00351};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 104..123
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 196..222
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 260..282
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT MOD_RES 41
FT /note="S-nitrosocysteine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600990-50"
FT MOD_RES 332
FT /note="S-nitrosocysteine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600990-50"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600990-52"
FT CARBOHYD 240
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600990-51"
SQ SEQUENCE 420 AA; 47352 MW; 83A19C4920496949 CRC64;
MAIAHAATEY VFTDFLLKEP TSEAKYKGIR LDLALDKMVT CIAVGLPLLL ISLAFAQEVS
VGTQISCFSP TNFSWRQAAY VDSYCWAAVQ RQDTGGLPLS LHKFFPYILL FVAVLVYVPA
LFWRFTAAPV LSSDLTFIME ELDRSYNRAI KLAKCLHSSP THLDAQSSMP DLTENCFKYP
LVEQYLKTKR FSHGLLVRYL LCRVVTFLVL VLACVYLCYY IQLSVTDEFH CNIRTGVLIN
DSSVPSPLQC KLIAVGVFQL LSYINLCVYL LLAPACIYAT VVPMRSSADF LKPYEMLPTL
GVMKFGTRAC NDLAMYLLFL EENLSELKSY KCLKVLELVK DQGDEHGPDT MLLLQSLGQV
KMDVLDGRLK MKISHASDTN MSRDQDGERN CLEMKEVSPL LLKDGAKKSE DEKVLRQRVI
//
