ID   A0A3B4E8K2_PYGNA        Unreviewed;       430 AA.
AC   A0A3B4E8K2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Par-6 family cell polarity regulator gamma b {ECO:0000313|Ensembl:ENSPNAP00000032023.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000032023.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000032023.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000256|ARBA:ARBA00004435}. Cytoplasm
CC       {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the PAR6 family.
CC       {ECO:0000256|ARBA:ARBA00008625}.
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DR   AlphaFoldDB; A0A3B4E8K2; -.
DR   STRING; 42514.ENSPNAP00000032023; -.
DR   Ensembl; ENSPNAT00000021537.1; ENSPNAP00000032023.1; ENSPNAG00000003604.1.
DR   GeneTree; ENSGT00950000183211; -.
DR   OMA; RNADCNA; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0032154; C:cleavage furrow; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0045176; P:apical protein localization; IEA:Ensembl.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0035844; P:cloaca development; IEA:Ensembl.
DR   GO; GO:0035050; P:embryonic heart tube development; IEA:Ensembl.
DR   GO; GO:0001841; P:neural tube formation; IEA:Ensembl.
DR   GO; GO:0048793; P:pronephros development; IEA:Ensembl.
DR   GO; GO:0048696; P:regulation of collateral sprouting in absence of injury; IEA:Ensembl.
DR   GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
DR   CDD; cd06403; PB1_Par6; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR000270; PB1_dom.
DR   InterPro; IPR034868; PB1_Par6.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR14102; PAR-6-RELATED; 1.
DR   PANTHER; PTHR14102:SF3; PARTITIONING DEFECTIVE 6 HOMOLOG GAMMA; 1.
DR   Pfam; PF00564; PB1; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00666; PB1; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   PROSITE; PS51745; PB1; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT   DOMAIN          18..101
FT                   /note="PB1"
FT                   /evidence="ECO:0000259|PROSITE:PS51745"
FT   DOMAIN          161..254
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          261..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..294
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..371
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   430 AA;  47261 MW;  9ABD5C068BBFA04E CRC64;
     TDKALHVSRS GSERLLNAVN VKSNIQPYGA EFRRFSVNRA KPGKFEEFFK LIIHIHRIAN
     MEVMIGYADV HGDLLPINND ENFSKAVSTA HPLLRIFIQR QEEVDYSNFG INTLTRKKKA
     VVTLRNDLNR KRPQIRIGMP QDFRPVSSII DVDILPESHR RVRLYRYGSD KPLGFYIRDG
     TSVRVTPHGL EKVPGIFISR MVPGGLAEST GLLAVNDEVL EVNGIEVSGK TLDQVTDMMI
     ANSHNLIVTV KPVNQRNNVV RSSRISGSSG QSSDSSGSGS FPAITHSPST ATVAHSYGHD
     DLDSDEESDI VIESSVSRPS RRSNVSQNQQ TSSAAPSPPS PPTRPQTRPP SVISTASFHS
     QPSLNGTGHS SLSYRLQRDL NLQQPHYHSA STRESNGSLH KILSSLRTDP RNSLALPPGG
     VEEDGMVITL
//