ID A0A3B4E940_PYGNA Unreviewed; 838 AA.
AC A0A3B4E940;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO5A1 {ECO:0000313|Ensembl:ENSPNAP00000032208.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000032208.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000032208.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_017554724.1; XM_017699235.1.
DR AlphaFoldDB; A0A3B4E940; -.
DR STRING; 42514.ENSPNAP00000032208; -.
DR Ensembl; ENSPNAT00000021867.1; ENSPNAP00000032208.1; ENSPNAG00000020001.1.
DR GeneID; 108428320; -.
DR CTD; 570033; -.
DR GeneTree; ENSGT01080000257410; -.
DR OMA; TLFICAQ; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd17404; MFS_SLCO5_OATP5; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF142; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 128..147
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 167..188
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 301..325
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 345..366
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 421..445
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 465..486
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 639..665
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 686..708
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 728..751
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 128..752
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 542..598
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 90780 MW; 0E3C6BC43B4DB7ED CRC64;
MASWNREDAA GGDSTVQVQP FPYVNEDSAQ ALKSKSLPAL SASQPPETDG TDNPPQGGQR
LLSAPRGDSP SRPERSTSSL AGLGSSRSSE AGGRPGGRRR AATVLWSQLR RVSVRRYVRG
VFADSRCFLF YMCYLTFIQS LMVSGYLSSV ITTIEKRYSL RSSESGLLVS CFDIGSLLVV
VFISYFGGQG QRPRWLAIGG VFIAVGAALF SLPHFISPPY QLEQLNTTGR GEGLCTSPNN
SRRDGPEACP RDQEDSEHSL YVALFICAQI LVGMGSTPIY TLGPTYLDDN VKKENASLYL
AIMYVMGALG PSAGYLLGGV LIGFYVDPNT VVNIDQNDPR FVGNWWSGFL LCAVAMLLVI
FPMFAFPKKL PPRHKKNRGK KKSVEDMTSD DDVIKAKSQA VSSSMGFGKD IKDLPKAALR
ILSNVTFLFV SLSYTAECAI VTAFITFIPK FIESQFGVPA SSASIYTGLI IVPSAGVGIV
LGGYIIKKLK LGARESAKLA MICSGVSLLC FSTLFIVGCE SINLGGINIP YTTGPTLTLS
HRNLTGGCNV NCGCRIHEYA PVCGSDGITY FNPCLAGCNS VSNDSSGIRN YSDCACVQSR
QVITPSGGNH DLQVVIVKTY LNENGYALAG KCERTCGTLV TFLIFLFIVT LITACAQPSA
IIVTLRSVEE QERPFALGMQ FVLLRTLAYI PTPIYFGAVI DTTCMLWQQD CGVHGSCWEY
DVTSLRFVYF GLAASLKFLG FLFIFLTWYS LKRREEHTHS HTRPVSPLDT VSQLICHAGG
QKGHARTRSC PVFLPRPPEH CHATTMVVGN ALSRGNSCPG NGLKAITPPI RSLEKVVI
//
