ID A0A3B4E9S7_PYGNA Unreviewed; 439 AA.
AC A0A3B4E9S7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Caspase 9 {ECO:0000313|Ensembl:ENSPNAP00000032580.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000032580.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000032580.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR RefSeq; XP_017549765.1; XM_017694276.1.
DR RefSeq; XP_017549766.1; XM_017694277.1.
DR AlphaFoldDB; A0A3B4E9S7; -.
DR STRING; 42514.ENSPNAP00000032580; -.
DR Ensembl; ENSPNAT00000022632.1; ENSPNAP00000032580.1; ENSPNAG00000020640.1.
DR GeneID; 108425555; -.
DR CTD; 842; -.
DR GeneTree; ENSGT00940000159698; -.
DR OMA; VQSICEV; -.
DR OrthoDB; 2873736at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0048696; P:regulation of collateral sprouting in absence of injury; IEA:Ensembl.
DR GO; GO:0097205; P:renal filtration; IEA:Ensembl.
DR CDD; cd08326; CARD_CASP9; 1.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR042147; CARD_CASP9.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR10454; CASPASE; 1.
DR PANTHER; PTHR10454:SF157; CASPASE-9; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PIRSF; PIRSF038001; Caspase_ICE; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00114; CARD; 1.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 1..90
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 174..306
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 349..436
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT REGION 106..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 48346 MW; 433BAC2C86A7D927 CRC64;
MEARHKKVLQ QNRTNLVTSL DPSDVYDGLL ARGIFTQDMI DEIKSSGTRR AQARQLVKDL
ETRGSRAFPA FLDCLRETGQ ASLAELLESG GPVSILVSPR VQPTVIPLPV PGNPENNRNG
KNHDGADASP KLVPLKPTTL PLDVLPSPSP DRDRPRPPRQ RRDSVQSYKM DASPCGICLI
INNVEFDASS NLKERKGSDV DCDKLEKRFQ SLNFHVVVKR NLKCKQIKHE LSSLAKMDHS
VYDCCVVVIL SHGTEASHNR FPGAVHGVDG PSVPVQIITN YLNGQNCSSL QSKPKLFFIQ
ACGGDQRDIG FEVSPDEVQP TPGGIDDQTD AIPLSSSSDS LSFSDEIDAR ASLPTPSDIL
VSYSTFPGYV SWRDTFAGSW YVETLDRVLE ENAVTDDLVT MLMVVNNEVS QISAKGLYKQ
MPGSFNFLRK LLYFQASKT
//
