ID A0A3B4EA43_PYGNA Unreviewed; 4292 AA.
AC A0A3B4EA43;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=FAT atypical cadherin 1 {ECO:0000313|Ensembl:ENSPNAP00000032106.1};
GN Name=FAT1 {ECO:0000313|Ensembl:ENSPNAP00000032106.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000032106.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000032106.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSPNAT00000037133.1; ENSPNAP00000032106.1; ENSPNAG00000023566.1.
DR GeneTree; ENSGT00940000157733; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 32.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 33.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF448; FAT ATYPICAL CADHERIN 2; 1.
DR Pfam; PF00028; Cadherin; 29.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 11.
DR PROSITE; PS50268; CADHERIN_2; 32.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3632..3660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3973..3993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..121
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 232..329
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 330..435
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 441..546
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 584..688
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 689..793
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 794..900
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 908..1005
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1006..1111
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1132..1194
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1210..1317
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1318..1423
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1424..1528
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1529..1626
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1627..1740
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1741..1845
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1841..1942
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1943..2043
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2044..2144
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2145..2251
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2252..2352
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2353..2456
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2457..2557
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2560..2665
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2666..2775
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2776..2881
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2882..2983
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2984..3088
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3089..3193
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3194..3298
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3299..3403
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3415..3506
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3655..3834
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3840..3877
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3879..3913
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3916..3952
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4081..4108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3867..3876
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3942..3951
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4292 AA; 472256 MW; 4174B73641E90013 CRC64;
MPILDANDLR PLFSPTSYSI SIPENTPIRA SIGRVSATDA DTGTNGEVYF SFKEWTAMFS
IHPTSGVITL TGKLDYPEMP QYEIDVLAVD RGLKLSGRSD VSSTAKLTVQ ILQSNDHAPV
VKAVPLTPRN TTKDPTYALV SVEDDDEGQN GEIASLSIVA GDPLQQFKAI RTSPGSKEYK
IKANKEVVWE GHDFGYNLTL QAKDKGNPPK FSSAVVVRVK PPYEKMEALQ FEKSIYRVTL
SEFAPPHSPV VMVRAVTKLP NLKYLLQYKM QQHRNPFTIN ENTGLITTVE SVQAEHVSQY
EFDVTTSNGQ SSTKVVVNVI DMNNNAPKFQ QSKYEASIDE HVPVGTSILT VSASDDDEGE
NGYVTYSIVS MNKKPFAIDY FTGIISTSEG LDYEMMPSKF YLRVRASDWG SPFRREAEAV
VLISLNNLND NQPLFENIDC EVALPRSFGV GEQIIVVSAI DADDLGVVRY HISAGNERDF
FELDPPSGVL TLKKPLIDGD GKEHPFHALH IEANDGEISS SPMLLNITVV SSLKEIRSKC
VETEALRRLA EMLLFGSKLH TETEMVGEFG DMHSVNNSVP QFAESIPSQI EVREDLPVGN
SVVLLKATDA DNGFNGKLLY VISGGNVDSC FMIETDTGWL KVLEPLDRET TDHYTLNITV
YDLGLPQKSS SHILEISVLD VNDNGPEFLE HEYSVDIRED SAAGTDIIQL EATDKDLGIN
GEVSYSFLTK TDKFDINEET GIVTVKSPLD REVNPCFALK VAAYDKATHD PQLMSTVILN
VMLEDVNDNA PTFFPLHYRV RVWEDIPVGT LILWLEAHDP DLGQSGQVRY SLTDDADGSF
QVDKVSGAVY LSQPLDFERK QAYNLTAKAK DRGKPISLSS VCFIEVEIVD INENLYRPSF
PFFVDWGSVS EDAPVGSSVM EVTAHDEDEG RDGEIRYAIH DGSGLGVFTI DEVTGVIRTQ
EILDRETTSH YWLTVYATDQ GVVPLSSSVE VYINVQDVND NAPQTSEPVY YSSVPENSPK
DMSIMQIQAF DPDSKTSDKL TYTITSGNPQ GFFNIDSQTG LIMTTSRKLD REKQEEHILE
VTISDDGIPS MYTVIRVVMK VQDENDNSPQ FLEKVYKIKL VERPKAIRWK PVYRVIAHDR
DESPHSEISY SIEEGDEHRK FFIEPKTGLI SSKEAFSAGD YHILTIKALD NGWPQKWSIC
RLHIEWIAKP EPPKQALVFE ETSLQFSAME SDPVGHMVGV ISTQPLDSPV WFDIKGGNVD
SRYNVEKGSG TIIIAKALDA EQQLNYNLTV EATDGTRSIS TQVLIQVIDT NEHRPKFGQA
KYEISIPEET QPGMKILEIS ATDKDEKNKL FYTLLSSTDP HSLKKFRLDP GTGFLYTTEE
LDHETMHRHI LTVMVRDQDV PVKRNLVRVI INVEDGNDNA PWFTSSWYTG RVFETAAVGS
AVLQVTALDK DKGQNAEILY SIESGNHGNS FSIDPFLGII KVAAELSSDQ KSQYELEVKA
SDKGEPPLSA FTTISITVTI SDNAEPKFHR SPITAEISEA APVGSFVTMV AASSQSSVFY
QIKEGNVNGT FDINPNSGAI VTQRKLDYET LSSYKLTVQG TNMAGMASQV AVLVLIKDEN
DNAPVFTQTE FVGFVSEGAA PRSMVLTNKN TPLVIHATDA DEDANARLVY QIVEPFAHNY
FTIDSGTGAI QTISGLDYEQ QSMFHFTVQA HDTGLPRLFT RHIANVTVHV TDVNDCEPKF
SQDSFETTLL LPTYKGVKVI LLNATDDDSP PNAKLLFSIL DGNIHNKFRI DHISGEIFVQ
NATELHSRYI LTVRVSDGRF MSTATVKIKV RDNKNHGLKF TQEIFTASIQ ENSSERETLA
IIATVGNKMN EPLFYSILNP DDRFDIGCTS GVLFTTGVPF DREEQDTFDV IVKVTNEHED
AVTAHVLVKV IVKDVNDNAP LFVDLPYNSV AQMDAEVGTV LRQVTAVDID VDRNSVIKYH
LKGHDEYFQI NPSGEISLKR PFEQESLNTK YVLNIIAEDG GDQALSSTAQ VMITVVNKPT
PVFERPFYKI EVPEDVQLHA SVLQVLANES VGPRTVYRIY EGDPFGHFSI DFNTGVIQVI
QPLDYETHPA HRLSIQAMDS LTGVYSEVFV DIILEDVNDN APIFHMKYYN VSVPESAMIG
TSVLQVSARD LDSGSNKEIS YQLYAKNGTI SDHFRIDGQS GVIWTTALLD YETEPMHELT
VRALDGGAFQ LYSEVMVVVL VADVNDNPPV FAQQLYNTTI SEHSPPGHFV ACVQASDADS
TDTGKLEFSF LSGNEDNIFG IDKSSGEIVI SSYQKPIVAQ YNLIVFTTDG VFTAFSEVKV
KVISANLHSP SFTQDEYVVE LLENSAVGTL VTQVEVHDRD SGIYGEVTLF IVNDVARDKF
TLNAEGQIHT TESFDRENPT EKVIHINILA KDGGGKVGFC TVTVILSDVN DNAPQFRLSE
YKAAVQRDVP RGTTVIKISA VDEDEGSNAD IIYAIDSDIG HFKIHPLSGA VVTKGNLMEL
ENGLCSFYVK AKDSGSPPRQ SVIPVSIKVL PSDLPMLKFA EELLRLELAE DLPVGTEINV
IQSERTQPVI YNLVRGNTPE SNKDDVFVIN SNTGKLKLAK RLDYEAIKWF QLTIQVQGTE
GSMEVMSVID VNIHLKDVND NSPQFDSFPY QSFLVENLSG GTSVVQVTAT DLDSGVNGLV
TYSLDENQEN PEVLELFAVD SETGWVTTVT EIDREKRNMY RIAIIAKDRA PEIHMTGTTV
VEVTVVDLND NPPVFTQAVY KARVREDEST PGTIITVLST TDSDSEEVNR RFSCFITGGD
PRGQFNLEYE DGACIVMTAK TLDREDRGHY LLNITATDGT YMARTAVELT VLDANDNSPV
CEKGLYTGTV PENSPAGKFI LLVSASDPDI QSNAEITYRL AGDGAESFRM DSATGTLKTL
LPLDREEKDV YNLTVQAVDG GNRFCQVDVV ITVEDVNDNA PVFTSDLYYI SVFDNTQPGA
YLARLQASDA DTGLNSKISY LLEDSAGGLF SIEEQSGIIS LVKPLSRQVM AGYRLKVRAA
DHGSLRTLST LSSVEVTVLD ANHHPPVFEH RDYVSIVPED VAVGTLLLSV FAASSNAQAN
AQTSYSITSG NKQGAFSIDS QTGNIFVIAP LDYEAAREHY LTVKATAGGQ ETLSDTATVT
VHLTDVNDNS PVFSQELYSA VVSEDSLPGW SVLTVMANDF DGPSNNLIHY SIVDGNQDSP
FIIDAVSGVL KVARQLDREK VGGYKLTVLA SDSGNPPKSS SAAINMTVAD VNDNPPVFSQ
ANYSLIIQES LPAGASVLQL SVSDRDAPQN GPPFSYNILK GNEGKSFSID QQGVIRTTTS
LRSSEKDQYV LHIQVSDSGK PPLQSSALLN ICVAQTSLYP PSVLPQDVFI LVQGEEYPAG
GILGRVNATD LDKHDTLTYT LQPPGHDLIS VSGSDGRLLA RRGLDVGRYP LNVSVSDGRF
SSLASITVHV RQVTQQMLDG SVSVRFAAIT AEDFIQEHWR NFQRAIRSIH SRAGLYTKQS
DMQILSLQPV EPEGDLDVLM FLEKSGGAGS SLEPLLQNLN TSSVALQELS GLRVVRVVTR
YCSNAECPDH MCRKVVTLDS SSMAVYSTAR RFWTSLLMIQ SVTPLMFLLV CVVGGAIMTF
SENSYIKYHL RKSTRAEMKF SLRLKTFSSH GTVMFVKGRG YSLLEVVGGR LQCQFDCGSG
PVTMSVHSVE VNDGLWHSVE LEVKGNRARL VLDHLHSASG ISSGALPCLG LDKQVILGGH
AGLLGSRPRR SLPLSGSLQG CVDTVLFNGQ SLFLQSESLS GVVVEDTVGV TPGCGMSLTP
DQDCTSNPCL NGGSCSQRLN GGYYCRCNSL FVGDHCELSI SPCVSNPCLY GGTCIQNNED
YYCRCRGHII GCFITLLNEC LRLPCLNGGW CVNTYGSFNC SCSPGFSGRL CEMENEVHNV
FISTSWNMGW AELVGILIFL AAIFVLALLF VLIRTGLCDP SKDEQEKEKY RAVDAYIQRT
YLDCRPRRDT FPDTPPQVPV KPLSYNPSIR TDSHKDIDGS SFTPDVTFGL KKSVAVCSVA
PNLPQRRASR PPTNSDSTQK PDWDEEGGKP MLIQAKTTKK RVPGFQSLLQ YEFVQMPSMY
PDINDMYPRT HVPDLDYLAE GDDVEANILP PPGHFPHDEP LSSLHSIART SGPCLTTCSL
QQHSLGHWQP NQTVQVVPQD SVEGPFELMP GSIYSGSARQ EGQGTFPSLL HTSAHLSNNG
EDLDPMMCDL KSLDKSVSSG ISTPMMKKNV AH
//
