ID   A0A3B4EAS2_PYGNA        Unreviewed;       331 AA.
AC   A0A3B4EAS2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=RLA class I histocompatibility antigen, alpha chain 11/11-like {ECO:0000313|Ensembl:ENSPNAP00000032394.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000032394.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000032394.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|RuleBase:RU004439}.
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DR   AlphaFoldDB; A0A3B4EAS2; -.
DR   Ensembl; ENSPNAT00000022313.1; ENSPNAP00000032394.1; ENSPNAG00000021410.1.
DR   GeneTree; ENSGT01100000263531; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd07698; IgC1_MHC_I_alpha3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   PANTHER; PTHR16675:SF235; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP BETA 1 CHAIN-LIKE [PROVISIONAL]; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..331
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017282081"
FT   TRANSMEM        289..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          200..285
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   331 AA;  37838 MW;  05E3590F7467DC38 CRC64;
     MIKPFPLFIL LFMCYHLAVQ DSHSLDYFFT GVTPGINYAE FAVVGHVDGL QGGYFDSNSR
     KVILTGEWLK DNKDEEHWNK ITKISQFYQE DFNGIIPAVM KLFGQTGGIH TWQWTIGCEL
     HGNRTKRGYS RYGYDGEDWL TLDLSTSTWT AANAKAVITK QEENTAKAKG HKNFLENDCI
     EWLQKYVEFG RSTLERKVPP EVSLFQKDSS SPVVCHATGF FPKAVMISWQ KNGEDLHEDV
     ELRETLPNQD GTFQKRSILT VSPEELDRHN YTCIIQHSSL EEQVSWKPLV LWIGTIIAAV
     VTVLLIFICV GVFVWMMKQH QSDQHSKGAH L
//