ID A0A3B4EB84_PYGNA Unreviewed; 4104 AA.
AC A0A3B4EB84;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=PKHD1 like 1 {ECO:0000313|Ensembl:ENSPNAP00000032564.1};
GN Name=PKHD1L1 {ECO:0000313|Ensembl:ENSPNAP00000032564.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000032564.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000032564.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 42514.ENSPNAP00000032564; -.
DR Ensembl; ENSPNAT00000022593.1; ENSPNAP00000032564.1; ENSPNAG00000021123.1.
DR GeneTree; ENSGT00940000157594; -.
DR OMA; WVTNANN; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 11.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR039448; Beta_helix.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR46769:SF2; FIBROCYSTIN-L; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF13229; Beta_helix; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF01833; TIG; 12.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 10.
DR SMART; SM00710; PbH1; 8.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF49503; Cupredoxins; 1.
DR SUPFAM; SSF81296; E set domains; 12.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 338..492
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 2100..2220
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 2961..3090
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
SQ SEQUENCE 4104 AA; 445765 MW; AC8696AF3E10F387 CRC64;
KVFFRQQQYI YICVCVCVCV SQRVDRVTPN YGSINGATRL TIDGQGKQRR TESTDIFTHL
HVNKNDNKHL NCVSLFELLT FPVSHVGSSH SENLISACTS VFSRAMPEDD YEVHVKVDGV
PIPASSVCWG MKWYYWCTFY TRWYNTPSIH KTTPLTGLPG TLVTLQGRIM TDVYSSSTGA
SPNGRNVRFV RAYMGGMPCV LLKPNSDELY GLRLDYMYSD WGSMSCKMTG TYVGHHNFSY
IIDGEFGRSL PDFQVYSVSA LNKISMFQTY AEVTGVSPSE GSTLGGTLLT IHGHYFDKTD
RPAEVLVGGR KCEVQSLTDE TITCRTPEYD WSNKTVFPGG RGIKMETWIN TNVRYLEDVL
AYNSSQPGYS VQWVDSLSYE WPGEIQYLVA RLSGFFVPTE TDNYYFLIKG SYRFQLYFST
TGRPQDKVKI AYLDHWGYSY NTSSTQRSKV MHLEKGKAYY VEVLLQQYTM TASIDVGFFK
ERSPFTAQQT QEAVNEKQVI QASYDVLDEK QVLHFEGWSP AIPVQELQSV TISSDCFSVG
TCDNTYYTLS YGAQRTGSVL SAELNALWTI KPDTVTVTKQ DLDTLTEYNI TFISNRGDFD
DLHYWTNLPG VNITVRELRK GRADLNSFTL LWGGIPSSPL PYQASETQVL SALGEMVSAK
CPQELLSVEN SEVKYFRDYE SAYKGFAGDL SNRGTIVEDS EPFCGRWSLM NPTVLFRWDD
VTPSGVNYEP VPLQHDAQYF LCRWQYTCVD LLEALQTRYA GSNYKLQELR LHRDTGDYYI
DTVQLRAATA TDINGALQRR RPPALANSGH FFQRISVHKL SNASHVSYEI TASPYNCAFG
VPLMEVGFLQ VSRAGRFTED ALVLVQNNAT VTVTRTQRAS PPLSGYFSAE IFGQRVEGLA
VDISAKDLQY ALQGIPDLGQ LSVTRTGDCK GYSWYIEWLT MPGSQPLLQI NDSTVAGVNS
SVTAQVKEHG GLFKQSIMGD FLRVPTNKTQ VQVLINGIPS KCSGDCGFTW SAAKTPTVTG
ISPSQGASAL GTVLTISGSG FVGGNASVQI GNVQCSVLQV TSTSLTCRVG PASAGLYPVS
VSFPEVGYAL PPGGNPFNFT YQMGVTSIEP TAGSVTGGTN IVISGYGFGY DTVATVGSAS
CDVVYVDSNQ LRCRVPAGSA GAQNVTLKSG EMEATANDSF TYDNALTAVI TDVSPQTTTV
FGLRTLTIQG QNFEDQTNGS SVLIGSVDCV VLTWTNENIT CLLPSLPPGV YHVSVGMGNR
GSPQISAGVN ATIAYVLQVS GLSPQQGSLY GGTTVTITGS GFSPDLADNT VTLGGTRCEV
TAAWDHQLVY YGQGYAWSPA TVMASVGDTV VWKWNAPDFV SGLGYRVFSV ASASSTEFDG
VGFSSGNTKT ATGFFSYRFT APGVYYYSSG YVDVANQRSL QGVVNVRPLE EISSGLQVTV
AGFQALRTHV SPSPSDCVAS SECPGSNITS DSFSFRFSTC ASPTVDSISP LQGTVHDPIV
LRGSGFSNIS CANEVTVGNA SCRVTNSTST EITCLLSSDS GAPVLVPLPV RVRVNNLGAA
MLTMPSELSR RVVILPVVDS ISPSAGSTSG RTRLVISGSG LSGGTVTVAG VPCIIVSSNY
TQVLCDTSPS PPRTGSITVR VGAVSSSCSS DCSYEYSAAL APQVSSVYPS SVSGNQTTVF
VSGSNFGSSL ENIAVFADDF ILDVTNITDN NITVSVGALP AGPHSLQVVV RNKGLAIGSV
TLTSEPLASL QPTSGSLAGG TLLMITGNGF VAGNTSVMVG VYPCSILQVT PSTVQCLTRS
YDEQVVQVKI QVFGVIYPLL SFNYSHLQTP QVTSISPTTG PSGTAITISG SGFGSEAGLV
SVNIDGVPCA VSSVTDTEVR CTAGEHAGGT YPVTMTHQAK GLAQSQSIFT YELRLTQVSP
NEGSYAGGAV VAVQGTGFDP ISSKVLICSK ECSVRRNASS STALYCEVPP NNVCMFHSEQ
ACMVMVLNTY ASANITNGYT YKSSLTPVIT DVSPRRGGTA GGTVLTITGS GFRSIGGNIT
VTIAGSVCDV RSVNETKVIC VTNAQPMSQM AKVRVQVGDK GIAQMDRADF FYIDVWSSRY
TWGGESPPEK GTFAVITKGQ TILLDVSTPV LKMLLIQGGK LIFDEADIEL QAENILITDG
GALQIGTEDQ PFQHKAIITL HGHLRSPEIP VYGAKTLGIR EGVLDLHGIP IPVPWTRLAQ
TARNGSRAIT LMHAVTWRVG DEVVIASTGH RYSQIENEVR IIAAVSADGR TLNLTQPLKY
THLGESITLP DGTVFEAKAE VGVLTRNVVV RGSVNQDWND LIPACPDGFN TGEFATQTCF
QGRFGEEVGS DQFGGCIMFH APRPNENLAV GRIEYVEIFN AGQAFRLGRY PIHWHLMGDL
KLKSYIRGCS IHQTYNRAVT IHNTHRLLVE HNVIYNIMGG AFFIEDGIET GNVLQYNLAV
FVKQSTSLLN DDLTPASYWV TNPNNTIRHN AAAGGTHFGF WYRMLDHPDG PSYDSNICQK
RAPLGEFYNN TAHSQGWFGL WIFKEFFPTQ QGTCGSYTPQ PAVFRKFTSW NNDKGAEWMN
VGSVQFSEFL MVNNERAGVE TKRIIEQFVS GWGLNGGAAL VNSTLVGHVD ELGLGSSFCT
TRGLILPLDD GMSILNTRFI NFDRPSCAAI SMASITGTCS SSCGGWSAKF SGIQFYQTPN
KAVFRWEHEV VFIDTDGSLT GNPGNKVLPK SNLLDPAHCS YNASWSMGFP GSVCDNTTSF
HRLVFNNPSY MLFFRDAILT NAYGSTIVPF TWQLITPGYG WMALLPSAQT YKWYFRDISQ
ITEISYSATF YGFRPQDYVI VNHNLTKSPD YVRIVDNRNS SSDPLNATVN VNGDWYFNKS
SNDLFYMVSG QTRSASRGKR SVDRSTTDIY VWFSVYNCFY PNCIEPKPSP SGTLPPGTLA
PMLSFLQVLS YWQTVNRASL PAAFCPETST LVSTGIWMIL DIAIPSLNKL AVLGVLEIPD
TMNSTSSSLP EYRSVVLNAT YISIQGGRLI AGSSDQPFRG DLQIILRGNR YTPEWPLSNG
QNQGSKVLGV FGTLDLYGLP HNVYRTKLAS TAQAGSNTIS LQEPVDWQAG DEIVLSTSSY
DPGQTETRTI TAVTNNNLTL TLDQPLTYTH ISESYTVDGT SQSYRLASDV GLLSRNIKII
GQDYPNLFTE SFGARVLVGA FSRGGISYRG KARIRDVEFY HTGQEGWTNN PDPRYSLAFL
NLGVNESYIK GCAIHHGFAP AIGIFGTDGL SVDDNVIHHA VGEGIKVWGN NNVIRGNLVT
MTLWRSRAEA YGFSWNAAIE ASQGTNVVLQ GNIVAGYERV GFRIDGEPCP GYFSAVAQWQ
QNEAHGGLYG VYMNGDGLPG CSQIQDFTVW RSYDFGIYFQ VSMSVIVSNV TLVDNGMGIM
SLIYGPPSLS HVYSNKTVLV QNALIVGSSP NFNCSDSMPM DTNMFQGASS RAPRPLNGGK
SGISWPTFES SHNGAPVNAH NGLTSYNAIS GLLSVTDTTF AGFRNVCLSQ TDYMFMTNPG
NDDLQHPIYV KRITKIDSTE EAQVFIYRPD LSKVNPSDCV DMDCDGKKKA MLNDLDGSFL
GAVGAVIPQS EYEWNGNPRR GLGDYRIPKV MLTYLNGSRI PVNQIAPNKG VHDSSCTYMS
TWQAYKCLGL TYRMLVIESL DSDTEKRRLS PVAMLGDSYV DLLNGPQDHG WCFGYSCHKR
VSLFHSIIAT NRSFDIFFTS TTPQKLRLMM LNASPTETVR VAVFYSNPQR LDVYVNNRLV
TPTNADWNKD KTDYTLLKPN QTGQYLPSLS STLGSNFFDP DYKMMHVLLR GSDPIEIRTS
PVLFVAFNLP FMTEAEFFGD KLVTNLAAFL KVPPNMIRIT NIIREGSARQ RRSTGLTVQV
EIKQPPVNET SSNSTSDEQF AVLKNIADNL GQAAVSGNLS QSIGFNVSSV GVIPPSPPPS
DPSWSQVASQ EVTRQDPPVQ TVKSVSSLVV VQQPVAGIQP GLLSVQPCIM AVDKEGACVS
VGVTTLTITA VLKDANVNPV DGLYGNTTIP FSNCWANYTD LAISIPGKNL NLAFTLNNWS
AQSRSFTVLA VPSVAGTSPS PKLP
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