ID A0A3B4EBF0_PYGNA Unreviewed; 801 AA.
AC A0A3B4EBF0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Mitogen-activated protein kinase kinase kinase 20 {ECO:0000313|Ensembl:ENSPNAP00000032629.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000032629.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000032629.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017547855.1; XM_017692366.1.
DR AlphaFoldDB; A0A3B4EBF0; -.
DR STRING; 42514.ENSPNAP00000032629; -.
DR Ensembl; ENSPNAT00000022728.1; ENSPNAP00000032629.1; ENSPNAG00000020757.1.
DR GeneID; 108424365; -.
DR CTD; 559247; -.
DR GeneTree; ENSGT00940000163262; -.
DR OrthoDB; 876955at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd09529; SAM_MLTK; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257:SF937; SAM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 16..277
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 339..409
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 621..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 280..328
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 621..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 801 AA; 90850 MW; AAE38FBEA4DDA18C CRC64;
MASLGASFVQ IKFDDIHFYE NCGGGSFGSV YRARWISQDK EVAVKKLLKI EKEAEILSVL
SHRNIIQFYG AVLEAPNYGI VTEYASGGSL YEYLSSDESE EISMKQIMTW ATEIAKGMHY
LHADAPVKVI HRDLKSRNVV MTADKVLKIC DFGASKFHSH TTHMSLVGTF PWMAPEVIQS
LPVSETCDTY SYGVVLWEML TREIPFKGLE GLQVAWLVVE KNERLTIPSS CPASFACLMR
KCWETEPSKR PVFKEILSTL EAMCNDSQLS DRCNSFLQNK AEWRREIEAT LERLKKLERD
LSCKEQELKE RERRLKMWER KLIEQSNTPL LPNLAIHAWT EEHVHFWISQ IFGTGHECEM
QLYADIFKQN HITGRRLLLL SEADMRDMGI TSKGHIIHLK AEIEKLTNDY LGLFHFPPLT
KDEWAREEEE EGWRKIVSLE LVFGYHWKAG TGPKDCKWKM YMELDGDEVA ITYIKDVTFN
ANRPDVEVLK MTKPPFVMDK WIVGISDKQT VDCIINYESD VKSPKSTRHV HLVQWSPASG
GDDIKAVELL IETTPLNGEG NYRSRSNSGI DPQWISSLRL KQMKENLTQE RNNGTPNSLS
AESMTLPQFL SAFGNQTSYA SAVRKSPNRN PFSPWASSRS SSPTLSTKLS SLHLGSKGSS
PSSTTSESAS ERERPVSAGA MYKYPRNNYH DCMTVPGAGD RKLSKVSTHI SQGATRGFQH
SGRPWNNSTV VPQNHPRIIP GMATVTAEKQ KNEAEETKGN EGGWIKVERK KPPKQEYKQQ
DQRQLRGRPR RGGRGGGRGR S
//
