ID A0A3B4ECX2_PYGNA Unreviewed; 1693 AA.
AC A0A3B4ECX2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Kinase D-interacting substrate of 220 kDa {ECO:0000313|Ensembl:ENSPNAP00000033690.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000033690.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000033690.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017537842.1; XM_017682353.1.
DR Ensembl; ENSPNAT00000024861.1; ENSPNAP00000033690.1; ENSPNAG00000022762.1.
DR GeneID; 108410983; -.
DR CTD; 335881; -.
DR GeneTree; ENSGT00940000156714; -.
DR OMA; TGHDYLK; -.
DR OrthoDB; 5474354at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011646; KAP_P-loop.
DR PANTHER; PTHR24116; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR PANTHER; PTHR24116:SF2; KINASE D-INTERACTING SUBSTRATE OF 220 KDA B; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07693; KAP_NTPase; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 9.
DR PROSITE; PS50088; ANK_REPEAT; 10.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 45..77
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 144..176
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 177..209
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 210..242
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 243..275
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 276..308
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 342..374
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 375..398
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 448..958
FT /note="KAP NTPase"
FT /evidence="ECO:0000259|Pfam:PF07693"
FT REGION 1238..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1290..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1456..1534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1582..1654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1368..1390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1411..1425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1693 AA; 187199 MW; 64A75328C0AC625F CRC64;
MDTTTSIKMT TMAIQNLFSY VEEENLAALK AHLDKFKEVD GRSDNGQTPL MLAAEQGSLE
IVQELIRRGA NVNLDDVDCW SALISAAKEG HVEVVKELLD SSAYIEHRDM GGWTALMWAA
YKGRVEVTNV LLENGANPNT TGQYSVYPII WAAGRGHAEI VKLLLKHGAK VNCSDKYGTT
PLIWAARKGH YDCVMHLLEN GADVDQEGAN SMTALIVAVK GGYTEVVKEL LKRNPNVNMT
DKDGNTALMI AAKEGYTEIV QDLLDAGTYV NIPDRSGDTV LIGAVRGGHV EIVRALLHKY
ADIDIRGQDN KTALYWAVEK GNATMVRDIL QCNPDTETTT KDSETPLIKA TKMRNIEIVE
LLLDKGAKVS AVDKKGDTPL HIAIRGRSRR LAELLLRNPK DGRLLYRPNK AGETPYNIDC
SHQKSILTQI FGARHLSPTE SDGDMLGYDL YSSALADILS EPTMQPPICV GLYAQWGSGK
SFLLKKLEDE MKTFAGQQIE PLFQFSWLVV FLSLMLCGSV ALLLGFTVDP KLAIAVSLSL
LALLYLFFVV VYFGSRREGE SWNWAWVLST RLARHIGYLE LLLKLMFVNP PELPEQTTRA
LPVRFLFTDY NRLSSVGGET SMAEMIATLS DACEREFGFM ASRLFRVFKT EDTQGKKKWK
KTCCIPSFVI FLFILGCLIT GMALLAVFKV DGHNQTVNAV LVAMASVVGL ALLLNCRTWW
QVTDSVLNSQ RKRLHSAANK MHKLKSEGFM KVLKSEVELM AKMAKTIDSF TQNQTRLVVI
IDGLDSCEQD KVLQMLDTVR VLFSKGPFIS IFASDPHIII KAINQNLNSV LRDSNINGHD
YMRNIVHLPV FLNSRGLSSA KKMCAPAPAN GDTGNSEGWH EELDRKLSQH SLGETAKFGS
KTTLNRRDTY RRRQMQRSVT RQMSFDLTKL LVTEDWFSDI SPQTMRRLLN IVSVTGRLLR
ANQITFNWDR LASWINLTEQ WPYRTSWLIL YLEETDGIPD QATLKTIYER ISKNIPTTKD
VEPLLEIDGD VRSFEVFLSS RTPVLAARDI RTFLPCTVNL DPKLREIIAD VRAAREQMNM
GGVTYPTLPL HDGAPRPTSI YSQQSSACSP TASYNGPYNP PGVSPQPHSA YYSGMAGPQH
PFYNRGTASV VSGTPSVLLS SMNTDTVCER LKVMEGIDQS MLAQYTATIK KANVNGRVLS
QCNLDELKKE MNMNFGDWQL FRGSVMEMRH VESQVLHEEA PSEQGSSMVG HGEPVRHRGA
SGHGGPGNTD TSPMYNFNLS FEELSNVGLD EQPRHANPPW MSTTHRTPSM SSLNSQESSN
DICKLTDKQQ AEYRNAYQEY IASMAQLEAA GSGAEKPVQP HPGQFMHSNS EDKNKDGGDQ
DGRKSYSKRS SGKPAVDAAD FAATDAATLD PISEEDEKLD HGSSKSLLGR KTSGEKVGLF
QSADLKLKAA GGLRYQKLTS DDEESEESDN APLLKDGKKP EPKRTESEER SLAKGKEYLS
DGMLDKKDSS DSGVRSNESS PNHSLQDEEA DLSQSERTNL IELDEESLAR KRGLPNSLSG
LQDPTVARMS ICSEDQCSLL ASSPEESWPS SKNYNLNRTP SNTTLNNNTN AQQGNRPRQP
GDGSNTTSSS NTTGSEVIVA PGSSTNTSST STTHNENVRV VHLKRGLNPG DPPEICAVTS
DTVTFGEERE SIL
//
