ID   A0A3B4ED99_PYGNA        Unreviewed;      1125 AA.
AC   A0A3B4ED99;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=IQ motif and SEC7 domain-containing protein 1-like {ECO:0000313|Ensembl:ENSPNAP00000033698.1};
GN   Name=IQSEC1 {ECO:0000313|Ensembl:ENSPNAP00000033698.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000033698.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000033698.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the BRAG family.
CC       {ECO:0000256|ARBA:ARBA00006248}.
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DR   RefSeq; XP_017553751.1; XM_017698262.1.
DR   AlphaFoldDB; A0A3B4ED99; -.
DR   Ensembl; ENSPNAT00000024789.1; ENSPNAP00000033698.1; ENSPNAG00000022682.1.
DR   GeneID; 108427785; -.
DR   GeneTree; ENSGT00940000156915; -.
DR   OrthoDB; 204547at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd13318; PH_IQSEC; 1.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR033742; IQSEC_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR10663:SF398; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1-LIKE; 1.
DR   Pfam; PF16453; IQ_SEC7_PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   3: Inferred from homology;
FT   DOMAIN          520..713
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          34..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          319..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          880..909
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          925..1027
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1045..1125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..408
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..453
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..501
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        886..900
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1004..1020
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1090..1108
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1125 AA;  127271 MW;  2B0718ACE8DC7120 CRC64;
     MSVCVVKSDM WCLQCNSEKT QSLLELELDG CVEGEVQSSE PTPSLDHGTG YGPLTHSSSI
     SPDTFDPSGY GQTAQPGPQR PRRPKLQHSQ SILRKQAEEE AIKRSRSLSE SYELSTDLQD
     KQVEMLERKY GGRFISRHAA RTIQTAFRQY QMNKNFERLR SSMSENRMSR RIVLSNMRMQ
     FSFEGPEKVH SSFFEGKQVS LTDEGGQMGP MVQTESGDMV PVHIAAPSGT SDLSDAITEL
     EDAFSRQVKS LAESIDDALN CRSLHEEEDR PEQVQDMQGK LPYQVKPVHG TDRRKLDEMM
     ASYSDVTLFI DEEDLSPPIQ LTHHSADPAS STESDQRAQS VNSSQEYWPI DNKEDKVDTD
     TSCRSTPSLE CQEPRLRMDH LPLLTIEPPS DSSADMSDRS EIDSVKRQNV YERTVAGPQA
     SPKHIAHGLP PRVPSLSRDE EPIRHRHRQL ESHLAINGNR QSKSESDFSD GDNDSINSTS
     NSTDTINCSS ESSSRDSVRE QTLSKQTYHK ETRNSWDSPA FSNDIIRKRH YRIGLNLFNK
     KPEKGIQYLT ERGFVPDTPV GVAHFLLQRK GLSRQMIGEF LGNRQKQFNR DVLDCVVDEM
     DFSGMELDEA LRKFQAHIRV QGEAQKVERL IEAFSQRYCI CNPGVVRQFR NPDTIFILAF
     AIILLNTDMY SPNVKPERKM KLEDFVKNLR GVDDGEDIPR EMLIGIYERI RQKELKTNED
     HVSQVQKVEK LIVGKKPIGS LHHGLGCVLS LPHRRLVCYC RLFEVPDPNK LQKLGLHQRE
     IFLFNDLLVV TKIFQKKKNS VTYSFRQSFS LYGMQVLLFE NQYYPNGIRL TSAIPGADVK
     VLISFNAPNP QDRKKFTDDL RESIAEVQEM EKYRIESELE KQKGVVRPSM SQSMSGLKKE
     AGNGTMSRAS LDDTYAMGEG LKRSALSSSL RDLSEAGKRG RRSSAGSLDS NMEGSIISSP
     RLRRRAPSSA RDCPSRPSPN PPSSSSSLLG SLFGSKRGKP SAQGYPPHPH PLPPHHPTLI
     SHKPHPTNLH HTAQAQMEVT HAYHGQRCPL PQNPPPYHHH HHYHPPQPGP GPRLYRQHSG
     HAPIPHTHTH HPQFAHHHHH HHRHHREQQQ PASSKPKHCG ISTVV
//