ID A0A3B4EF30_PYGNA Unreviewed; 321 AA.
AC A0A3B4EF30;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Spermidine synthase {ECO:0000313|Ensembl:ENSPNAP00000033826.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000033826.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000033826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867, ECO:0000256|RuleBase:RU003836}.
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DR AlphaFoldDB; A0A3B4EF30; -.
DR STRING; 42514.ENSPNAP00000033826; -.
DR Ensembl; ENSPNAT00000038156.1; ENSPNAP00000033826.1; ENSPNAG00000022761.1.
DR GeneTree; ENSGT00870000136521; -.
DR OMA; FLYHEMM; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.30.140.10; Spermidine synthase, tetramerisation domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_00198; Spermidine_synth; 1.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR030373; PABS_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001045; Spermi_synthase.
DR InterPro; IPR030668; Spermi_synthase_euk.
DR InterPro; IPR035246; Spermidine_synt_N.
DR InterPro; IPR037163; Spermidine_synt_N_sf.
DR NCBIfam; TIGR00417; speE; 1.
DR PANTHER; PTHR11558:SF11; SPERMIDINE SYNTHASE; 1.
DR PANTHER; PTHR11558; SPERMIDINE/SPERMINE SYNTHASE; 1.
DR Pfam; PF17284; Spermine_synt_N; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR PIRSF; PIRSF000502; Spermidine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01330; PABS_1; 1.
DR PROSITE; PS51006; PABS_2; 1.
PE 3: Inferred from homology;
KW Polyamine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00354};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}.
FT DOMAIN 6..241
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT ACT_SITE 161
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 321 AA; 36627 MW; 97DC3125E7DDA158 CRC64;
MDNIKDGWFT ETCTLWPGQA MSLQVEEVLY HKKSKFQDVM VFKSKTYGNV LVLDGVIQCT
ERDEFSYQEM IANLPLCCHP CPKKVLIIGG GDGGVLREVV KHPMVESVVQ CEIDEDVINV
SKKYLPGMAK GFFSPKLTLN VGDGFEFMKQ NQDAFDVIIT DSSDPVGPAE SLFKESYYQL
MKTALREGGI LCCQGECQWL HLELIKEMRT FCKTLFPVVD YAYCTIPTYP SGQIGFMLCS
KNSQTNFREP VRELSRDDIE SMHLKYYNPE IHRAAFILPE FARKVAKFIC PFEILKRILN
ICLCILLNDV LDQSDKGSRH F
//
