ID   A0A3B4EHB0_PYGNA        Unreviewed;       908 AA.
AC   A0A3B4EHB0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Patched domain containing 3 {ECO:0000313|Ensembl:ENSPNAP00000034684.1};
GN   Name=PTCHD3 {ECO:0000313|Ensembl:ENSPNAP00000034684.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000034684.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000034684.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   AlphaFoldDB; A0A3B4EHB0; -.
DR   Ensembl; ENSPNAT00000026762.1; ENSPNAP00000034684.1; ENSPNAG00000024113.1.
DR   GeneTree; ENSGT00940000158727; -.
DR   OMA; IIRASWW; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796:SF60; PATCHED DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        252..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        281..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        316..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        355..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        386..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        663..689
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        695..716
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        728..747
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        767..785
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        797..822
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          252..409
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   908 AA;  101951 MW;  7B4E4E997257A14C CRC64;
     MCRCKTDCLE KPLSSGFRCF GRLVGSHPWW FLILPLFVSG GLGAGFIFLR DRQANGIEDQ
     FTPVNGLAKR ERAFVQDHFR NTEDFSQLRL STEGTFGSLI ITSLKDNILL VDELTEVINL
     DQQVRRLNIE KPFASLCART GGTCVSNPLL DIINYTASKI SDIAIEYPTH KGVFLGSVLG
     DVQLEEGSSR ARSAKAIRLF YFLKEENSTE TAQWLKAFIH FFSNYTGQKT VSVSYFTSLS
     REEEFESSTA SVIPLFSITY FLAITISIIS CLRLDCVRNK VWVATFGVLS AGLAVLTSFG
     LLLFCGMPFA MTVASAPFLI LGIGVDDMFI MISCWQKTKV KDQVEERLAE TYKEAAISIT
     ITTLTDVLAF YIGLMTPFRS VQSFCVYTGT AVLFCYLYNI TFFGAFLALN GRREQGNRHW
     LTCMVVPEIK DNPDGNICCV GGAYDEQTDT EKEMPIHLFF KKYYGPFLTH SCTKVFMIIL
     YCGYLAASIY GCLQIQEGIE LKHLAVDSSY VVKYYDNEKK YFSQYGPSVM IVIKDDKFQY
     WNTSAQASLN LCLEEFNNLP MTSKDFHVFW LQYYMLYGES LDLNNETIFK TYLSEFLQSS
     GFSQDVNFTG NHILASRMFI QTVNISSAID EKNMLNAFRE TAEKCQAADM LVYHYAFIYF
     DQYAVIVSNT IQNVVVATLV MLVISLLLIP NPLCSIWVTF AIASVIVGVA GFMALWDVNL
     DSISMINLVI CIGFSVDFSA HISYAFVSSN EPSRNKKAID SLYNLGYPMI QAAVSTIAGV
     VVLAASPSYI FRTFFKIMFL VILFGLVHGV VFIPVILSLI GFCGKAHNSI KDENTTKQHH
     NMKDQSAFAC SNSGFASQNE FKMNPYAHEL SSVYSWFPRA SSKQRAVPDQ SLIFNNSLPW
     KNADPDCP
//