ID A0A3B4EHD2_PYGNA Unreviewed; 1166 AA.
AC A0A3B4EHD2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=MCF.2 cell line derived transforming sequence like {ECO:0000313|Ensembl:ENSPNAP00000035158.1};
GN Name=MCF2L {ECO:0000313|Ensembl:ENSPNAP00000035158.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000035158.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000035158.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4EHD2; -.
DR Ensembl; ENSPNAT00000027774.1; ENSPNAP00000035158.1; ENSPNAG00000025029.1.
DR GeneTree; ENSGT00940000157874; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11857; SH3_DBS; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR035532; DBS_SH3.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..173
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 571..751
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 769..885
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1068..1129
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 507..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1002
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1166 AA; 130954 MW; 5113C20EBB7AC4C1 CRC64;
MPLVTNEIMQ QESSPLCAAD IGPDLSKGFA FLSGGRGENG SPIIIFPEFP AFSELQEQEF
HNVLTYLTSV PSLSASGVGF ILVIDRRQDR WASVKGTLLR IAGSFPGNLQ LVLVLRPTTL
LQRTLSDFLF KFSKDEFKMK VPVIMLSSVT ELHSYIDRTQ LTQELGGTQE YCHEKWISHR
TAIEGFALMV KKTAQTLQAF GTELAETELP NDVEATSNLL TTHTEKKDKM KEDLKIALSQ
GGRLLESINE PFVSNPDYNM NHDELENLAT VQRLLGQLDE TETAFDDFWE RHQTKLEQCL
QLRHFEHNFR EVRAHLDQVA DKLSGFSEVG ISPAHGEHIL KELTNHEERT CEVLDRALAL
ASDADILIES SHYAVDSILP KCSELRAVCE EVGTVLKAKK AHLLKAMELH SSLEKATKWC
EDGIYLLASQ PVDKCQSQDG AEAALQEIER YLDTANQHKL TDLNGIWRDY ESVLTSDFRE
QVERVFQKQL SMQEMFEKRR ISLKKLAAKQ TRPVQPVAPR PEAIIKSPHS SPAHREKDSS
PDINNKKGDA LIQNGSRPPS LSEEEENLAV LRRHVMNELL ETERAYVEEL LCVLQGYADE
MDNPSMAHLI PITLHNKKDV LFGNMAEIYQ FHNKTFLREL EAYTDYPELV GRCFLERMTD
LQIYEKYCQN KPRSESLWRQ CSDCAFFQEC QKKLEHKLGL DSYLLKPVQR ITKYQLLLKE
LLKYSKGCEG SEDLQDALSS ILGILKAVND SMHLIAITGY EGNLSELGRL LMQGSFSVWT
EHKKGHAKVK DLARFKPMQR HLFLHEKALL FCKKREENGE GYEKAPSYSF KHSLSMSAVG
ITENAKGDNK KFEIWCNSRE EVYIVQAPTT EIKTAWVNEI RKVLTGQLKA CREASQQKTS
EQVSPLPNAV ISLSPFKTNQ KTVKKGEEKK VETTVPDSGL APSSKNTDKI KDEAVISPSA
DRAAVAKKRF TLQGFSNLKS QKGSPPSPDH KTKRHEIKSD PTPFGFRDAG PHVTLSRVKW
LSTSSLLQAK RRGFNKASLS MDASEENDGY SSAEDPLNSD PEDEGKKLSP GRYVVVADYD
KGGAQDLSVK SGDMVQLVRE GSDGQWFVRN LKNSKEGWMP AANLLTLIGE SKSSQSLTSS
EGSGSGNLST SSSCSETYTS FSDIKP
//
