ID A0A3B4EIJ5_PYGNA Unreviewed; 440 AA.
AC A0A3B4EIJ5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000035119.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000035119.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR AlphaFoldDB; A0A3B4EIJ5; -.
DR STRING; 42514.ENSPNAP00000035119; -.
DR Ensembl; ENSPNAT00000027669.1; ENSPNAP00000035119.1; ENSPNAG00000024873.1.
DR GeneTree; ENSGT00950000182881; -.
DR OMA; LERILXF; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR PANTHER; PTHR11629:SF90; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
PE 3: Inferred from homology;
KW Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 42..70
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 208..227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 239..255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 380..403
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
SQ SEQUENCE 440 AA; 50422 MW; 86AA7054A8E0C39E CRC64;
IQTQQIPPTF NRTNEFTKGF QTIVDAYGVS NYREINPAPY TIITFPFLFA VMFGDCGHGI
ILTLLAIWVI KQQEQLSRWK SEFVDVLVGG RFIILLMGLF SIYTGLIYND CFSKSFSICR
SSWRVRHMFH NKTLHDFGHL HLDPEIPGVY SGSPYIFGID PVWNIASNKL SFLNSYKMKM
SVILGVSHML FGMALSLVNY LYNVLLRFVP ELVFMLSLFG YLLFLILFKW TVRLRSETAP
SILLIFINMM LFSYQTDDKF LYSGQKALQM FLVLQALLMV PVMLLIKPLL IYRHRVQLQQ
QVRCSVSITC CEKLRKISVA MFMGDIFAYQ AIHTIEHCLG CISNTASYLR LWALSLAHAE
LSEVLWRMLL RGTLGCHPGL GSLLLALVFS CFALLTFAVL IVMEGLSAFL HALRLHWIEF
QNKFYQGAGF KFTPLSFTSL
//
