ID A0A3B4EJD1_PYGNA Unreviewed; 445 AA.
AC A0A3B4EJD1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Homer protein homolog 2-like {ECO:0000313|Ensembl:ENSPNAP00000035990.1};
GN Name=HOMER2 {ECO:0000313|Ensembl:ENSPNAP00000035990.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000035990.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000035990.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the Homer family.
CC {ECO:0000256|ARBA:ARBA00023606}.
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DR AlphaFoldDB; A0A3B4EJD1; -.
DR STRING; 42514.ENSPNAP00000035990; -.
DR Ensembl; ENSPNAT00000029786.1; ENSPNAP00000035990.1; ENSPNAG00000026415.1.
DR GeneTree; ENSGT00940000157324; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IEA:InterPro.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:InterPro.
DR CDD; cd01206; EVH1_Homer_Vesl; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045027; Homer.
DR InterPro; IPR044100; Homer_EVH1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR10918; HOMER; 1.
DR PANTHER; PTHR10918:SF2; HOMER PROTEIN HOMOLOG 2; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 1..109
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 109..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 164..226
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 109..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 50277 MW; ADC20A06CCB16F0A CRC64;
MEQPIFTTRA HVFQIDPTTK KNWVPASKQA VTVSYFYDST RNSYRIISVD GSKVIINSTI
TPNMTFTKTS QKFGQWADSR ANTVFGLGFA SEQQLMKFAD KFQEVKEAAK LARDKSQEKM
ETSSNHSQES GRETPSSNQV SSMNGTDDEK ISHTPDTMAL KSENDRLKTA VEQSNSNAKK
CETELQALRE SNARLLDALQ EANSSVENWK AQAAACQEEN NALKNKVSHT LSHTHTNTQR
CVTNVGITID YLFSPGSVFF RSCCCDIAQA LQNTGKNLVK PNGNCRTDWV YITIPTFRAG
YSFSLMRNCR TDSVYITIPT FRAGYSFSLM RNCRTDSVYI TIPTFRAGYL FSLMRNCRTD
SVYITIPTFR AGYSFSLTRN CRTDSVYITI PTFRVGYSFS LTRNCRTDSV YITIPTFRAG
YSFSLMRNCR TDSVYITIPT FRAGY
//
