ID A0A3B4EJG9_PYGNA Unreviewed; 1116 AA.
AC A0A3B4EJG9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=AF4/FMR2 family member 4 {ECO:0000313|Ensembl:ENSPNAP00000035913.1};
GN Name=AFF4 {ECO:0000313|Ensembl:ENSPNAP00000035913.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000035913.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000035913.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR RefSeq; XP_017556619.1; XM_017701130.1.
DR AlphaFoldDB; A0A3B4EJG9; -.
DR STRING; 42514.ENSPNAP00000035913; -.
DR Ensembl; ENSPNAT00000029614.1; ENSPNAP00000035913.1; ENSPNAG00000004777.1.
DR GeneID; 108429418; -.
DR CTD; 27125; -.
DR GeneTree; ENSGT00950000182974; -.
DR OMA; RTPVCIF; -.
DR OrthoDB; 4254515at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF15; AF4_FMR2 FAMILY MEMBER 4; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 854..1114
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 987..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..576
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..840
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 121865 MW; E17855045D5330AF CRC64;
MASQSGNMNR EDRNVLRMKE RERRNQEIQQ GGEAFPSNSP LFPEPYKVSK TEDKLSSRIQ
SMLGNYDEMK ETIGEPPLSK LMPKASGSST SEEKSMYSET RGGGGQSQSQ GNKWTPVGPA
SGASSSSSSK SQNRSSSGMQ SSHSSSQRSG SGGSSQRHER DFSSSSSSSK KSSKHEHKSH
ATSSPAKGTL NSSSHSRSLT AEHHGKERYR SKSPRDREAN WDSPSRVHSS SSSSSFPSGQ
HSSQTFPPSL MSKPGSMLQK PTAYVRPMDG QETAEPKTSS ESYGSQSHSS SMGDMKGNGK
ASLTKLKIPA PVEGSMTGDP SCVDEILKEM TQSWPPPLTA IHTPCKTEPS KFPFPTKDAQ
HTSFGGLKKC ISGKGTSTSQ QSKACDGDQN NMLHDDLKLS SSEDSDGEQD SAKRNPSASN
NSNNNSEVAE REDSSSHSGS ESSSGSESES ESSSTDSETN EQSCVPSPER EQPPANKWQL
DNWLSKMEDR EANTGRGYGS QGPKDSTPTP GRDLRAPQKG SESGRGRQKS PAQSEGGGTS
QRRFVGKKQP KKPEKPPVVE EPKGGLKVES EPPPEIPQHR ARAPNKGPRK PNIRKDPKSS
SSPRATQDKR KAKAQGKTVQ KSREFVDTES SSSESEGEES APSSSQTPKY VPVCVFSPIE
NTELLSPLSD PDERPPPPRQ LLVTIDLSLL SRVPGRLYKD IEVKVERDST GESKDFQKQS
GEKGASKGKR KHKNDDDGVK PDNKKSRQEE KPSHHKPNKE SSKRSVDKEK DPVPSPSMAL
QRTPKSEHQG RKRTASQSST SLPSSASSKE SGKSSSSSKH RKGEDKQSRS SRETKEKIPK
MENQLAVPPL SSDSSKRSRL LFEDRVHSAD HYLQEAKKLK HNADALMDRF EKAVYYLDAV
VSFIECGNAL EKSAQEAKSP FPMYAETVEL IKYTMKLKSY MAPDATSADK RLAVLCLRCQ
SLLYLRLFKL RKESALKYSK TLTEHLKNSL SNTQAPSPGM GNKAAGMPSP VSPKLSPGSA
GSYSSSSSSQ SGSSSVTIPQ RIHQMAASYV QVTSNFLYAT EVWDQAEQLA KEQREFFTEL
DKVMGPLIFN TSSMTELVRY TRQGLHWLRL DAKLSS
//
