ID A0A3B4EL33_PYGNA Unreviewed; 1246 AA.
AC A0A3B4EL33;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 2 {ECO:0000313|Ensembl:ENSPNAP00000037187.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000037187.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000037187.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017546589.1; XM_017691100.1.
DR AlphaFoldDB; A0A3B4EL33; -.
DR Ensembl; ENSPNAT00000032855.1; ENSPNAP00000037187.1; ENSPNAG00000004417.1.
DR GeneID; 108423655; -.
DR CTD; 553520; -.
DR GeneTree; ENSGT00940000155679; -.
DR OMA; DHIPKVC; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF187; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 239..425
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 466..584
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 631..748
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1011..1243
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 702..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 147..184
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 754..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 141724 MW; 4B1B659263776FD9 CRC64;
MQKSVRYNEG HALYLSVVAR KEGTKRGYLS KKTTENSRWH EKYFALYQNV LFYFDTEQSA
RPSGIYLLEG CTCERVPAPK VSTGGKETLD KLQYFLIVFG HDGQKPLELR TEEESECDEW
VEVIQQASYS DIIIEREVLM QKYIHLVQIV ETEKVAANQL RTQLEDQDTE IERLKAEIIA
LNKTKERMRP YQVNQEEEDP DIKKIKKVQS FMRGWLCRRK WKLIVQDYIC SPHAESMRKR
NQIVFNMVEA ETEYVHQLSI LVNCFLRPLR MAASSKKPPI SHDDVSSIFL NSETIMFLHE
IFHQGLKARI ANWPTLVLAD LFDILLPMLN IYQEFVRNHQ YSLQVLANCK QNRDFDKLLK
QYESNAACEG RMLETFLTYP MFQIPRYIIT LHELLAHTPH EHVERKSLEF AKSKLEELSR
VMHDEVSDTE NIRKNLAIER MIVEGCDILL DTSQTFVRQG SLIQLPSVER GKLSKVRLGS
LSLKKEGERQ CFLFTKHFLI CTRSSGGKLH LLKQGGVLSL IECTLIEEPD ASDEDSKTSG
QVFGHLDFKI VVEPADAPAF TVVLLAPSRQ EKAAWTSDIS QCIDNIRCNG LMTSVFEENS
KVTVPHMIKS DARLHKDDVD ICFSKTLNSC KVPQIRYASV ERLLERLTDL RFLSIDFLNT
FLHTYRIFTS ATVVMDKLAD IYKKPFTSIP VRSLELFFAT NQNNRNSSSG DHPNDKSPRL
CRKFSSPPPL SIPSRTNSPV RARKLSLNSP LNSRVGALDL STNPTSYSAA SSPTSANPTT
SPPPSINPRS PLDLSRGQSP SSPEQSPGAQ DDNADAPRID ALCGKLRRSI RRAVLESVSL
DKFIPESPQG SEAGDLSPCR SPSTPRHLRY RGPGVPAAEN SRCSVSPASA FAIATAAAGH
SSPPVFSNSE RMCDKEFIIR RAATNRVLNV LRHWVSKHSQ DFELNSELKM GVIGLLEEVL
RDPDLLPQER KATANILNAL SQDDQEDAQL KIEDILQMAE CPKAECFESL SAMELAEQIT
LLDHIIFRSI PYEEFLGQGW MKMDKTERTP YIMKTSQHFN DMSNLVASQI MSHTDVGSRA
SSIEKWVAVA DICRCLNNYN GVLEITSALN RSAIYRLKKT WAKISKQTKA LMDKLQKTVS
SEGRFKNLRE TLKNCNPPCV PYLGMYLTDL AFIEEGTPNF TEEGLVNFSK MRMISHIIRE
IRQFQQTPYR IEHQPKVTQY LLDKALIMDE DTLYDLSLKI EPRLPA
//
