ID A0A3B4ELA3_PYGNA Unreviewed; 162 AA.
AC A0A3B4ELA3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Caveolin {ECO:0000256|RuleBase:RU000680};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000035966.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000035966.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes.
CC Interacts directly with G-protein alpha subunits and can functionally
CC regulate their activity. {ECO:0000256|RuleBase:RU000680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202,
CC ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680}. Golgi
CC apparatus membrane {ECO:0000256|RuleBase:RU000680}; Peripheral membrane
CC protein {ECO:0000256|RuleBase:RU000680}. Membrane, caveola
CC {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU000680}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the caveolin family.
CC {ECO:0000256|ARBA:ARBA00010988, ECO:0000256|RuleBase:RU000680}.
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DR RefSeq; XP_017573209.1; XM_017717720.1.
DR AlphaFoldDB; A0A3B4ELA3; -.
DR STRING; 42514.ENSPNAP00000035966; -.
DR Ensembl; ENSPNAT00000039611.1; ENSPNAP00000035966.1; ENSPNAG00000004040.1.
DR GeneID; 108439352; -.
DR CTD; 858; -.
DR GeneTree; ENSGT00950000183006; -.
DR OMA; TRIFMDD; -.
DR OrthoDB; 3740765at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070836; P:caveola assembly; IEA:InterPro.
DR InterPro; IPR001612; Caveolin.
DR PANTHER; PTHR10844; CAVEOLIN; 1.
DR PANTHER; PTHR10844:SF3; CAVEOLIN-2; 1.
DR Pfam; PF01146; Caveolin; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU000680};
KW Golgi apparatus {ECO:0000256|RuleBase:RU000680};
KW Membrane {ECO:0000256|RuleBase:RU000680, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 83..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 162 AA; 18391 MW; 62332867FCFE5D90 CRC64;
MGLEKEKAET SVIMDEDLFN RSIEPILTKK EKLFPTEPDR DPNDINSHLK VEFEDIIAEP
SSTHSFDSVW IWSHAVFELL KFIFYRLLTT LLAIPMAFVA GIVFGLLSCV HIWVVMPLVH
SCMMALPSIQ VIWASLMDMF VGPLFHSIGR VLSSVNVKTV QN
//
