ID A0A3B4EMR9_PYGNA Unreviewed; 306 AA.
AC A0A3B4EMR9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Kazal-type serine protease inhibitor domain-containing protein 1-like {ECO:0000313|Ensembl:ENSPNAP00000036471.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000036471.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000036471.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_017545269.1; XM_017689780.1.
DR RefSeq; XP_017545275.1; XM_017689786.1.
DR RefSeq; XP_017545280.1; XM_017689791.1.
DR AlphaFoldDB; A0A3B4EMR9; -.
DR Ensembl; ENSPNAT00000031061.1; ENSPNAP00000036471.1; ENSPNAG00000005812.1.
DR GeneID; 108416976; -.
DR CTD; 568748; -.
DR GeneTree; ENSGT00530000063555; -.
DR OMA; PCKAKPI; -.
DR OrthoDB; 3019991at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR CDD; cd00104; KAZAL_FS; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR011390; IGFBP_rP_mac25.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR14186; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14186:SF23; KAZAL-TYPE SERINE PEPTIDASE INHIBITOR DOMAIN 2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..306
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017258808"
FT DOMAIN 35..120
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 95..162
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 164..261
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 264..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 306 AA; 34022 MW; C8B634C334474454 CRC64;
MLCLTAMLTL LLACLSEPLP LEHLRHLDWQ RGMRPGERCP KKCQPELCPD ARLLQSCVSG
QVRDPCGCCW ECGNGEGQLC DPEPWTGSTF FGRCAEGLRC KAPRRDPSMK EEPKPVCVCT
KQEMLCSSDG KTYENVCQLR AAQRRLGERQ KVTVAHHGPC KAKPIITYAP RDIITLEGSD
VLLSCEVSSY PLASIQWRKE GDSVFLTADD SSRAIQARGG PRRFELTGWL QIHGVGPDDA
GVYTCAARNA FGEVSASARL RVMHRGSPQN REIPKRKNEA HNTSFNDAES EDDEDYEGQP
SGYMYL
//
