ID A0A3B4EMU0_PYGNA Unreviewed; 864 AA.
AC A0A3B4EMU0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=CLCN6 {ECO:0000313|Ensembl:ENSPNAP00000036491.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000036491.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000036491.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR RefSeq; XP_017561286.1; XM_017705797.1.
DR AlphaFoldDB; A0A3B4EMU0; -.
DR STRING; 42514.ENSPNAP00000036491; -.
DR Ensembl; ENSPNAT00000031129.1; ENSPNAP00000036491.1; ENSPNAG00000027451.1.
DR GeneID; 108432145; -.
DR CTD; 1185; -.
DR GeneTree; ENSGT00940000159291; -.
DR OrthoDB; 1089019at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03685; ClC_6_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002248; Cl_channel-6.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF136; H(+)_CL(-) EXCHANGE TRANSPORTER 6; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01117; CLCHANNEL6.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 78..99
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 135..156
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 177..194
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 200..217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 331..349
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 459..478
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 515..540
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 802..862
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 864 AA; 96953 MW; DD9F22C010E5E760 CRC64;
MACCGSCLCC QCCCCTEGET RTPEELTILG ETREDEDEIL PRKDYESLDY DRCINEPYVE
VLEGLDRKKT KKYEAVKWML VFAIGVSTGL IGVFVDFFVR LFTQLKFRLV GKSVEECSEN
GCLALSLLEL LSFNMAFVFI ASVLVLIEPV AAGSGIPEIK SYLNGVKIPG IVRLRTFICK
AIGVLFAVAG GLFVGKEGPM IHSGAIIGAG LPQFQSITFK KIRFHFPYFR SDRDKRDFVS
AGAAAGVAAA FGAPIGGTLF SLEEGSSFWN QALTWKVLFC SMSATFTLNF FRSGINYNKW
GSFQLPGLLN FGEFKCPDGD KNCHLWTAVD LAFFVLMGVV GGLLGAMFNC INKRLAKYRM
RNVHPKAKFI RVLESLLVCM LTTVVVFMAS MTLGECRDLA PPTANNTTAI VSANEDVNST
IRQFFCSNRT YNDMATLFFN PQETAIHQLF HQDATFSPVT LLLFFVLYFL LSCWTYGVSV
PSGLFVPSLL CGASLGRLVA NILKMNLGMH IYSGTFALIG AAAFLGGVVR MTISLTVILI
ESTNEITYGL PIMITLMVAK WTGDFFNKGI YDIHIHLKGV PLLEWETEVE MDKLTASDIM
EPNLTYVYPH TRIQSLVSIL RTTVYHAFPV VTENREYEKE FMKGNILVSN NIRFKKTSVL
TRAGEQRRRC QSMKSYPSSE LRNVCDEQVG VEPAEEGQDI LQQMLERRHM PYPNLYPDQS
PSEEWSMEER FRPLTFHGLI LRSQLVNLLI RGVCYAENQS SASQPRLSYA EMTEDYPRFP
DIHDLDLALL NPRMIVDVTA YMNPSPYTVS PNTHVSQVFN LFRTMGLRHL PVVNAVGEIV
GIITRHNLTH EFLMAKLRQH YITI
//
