ID A0A3B4EP83_PYGNA Unreviewed; 469 AA.
AC A0A3B4EP83;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Peroxisome proliferator-activated receptor alpha {ECO:0000256|ARBA:ARBA00019236};
DE AltName: Full=Nuclear receptor subfamily 1 group C member 1 {ECO:0000256|ARBA:ARBA00032723};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000037079.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000037079.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR RefSeq; XP_017572321.1; XM_017716832.1.
DR RefSeq; XP_017572322.1; XM_017716833.1.
DR RefSeq; XP_017572323.1; XM_017716834.1.
DR RefSeq; XP_017572324.1; XM_017716835.1.
DR RefSeq; XP_017572325.1; XM_017716836.1.
DR RefSeq; XP_017572326.1; XM_017716837.1.
DR RefSeq; XP_017572327.1; XM_017716838.1.
DR RefSeq; XP_017572328.1; XM_017716839.1.
DR RefSeq; XP_017572329.1; XM_017716840.1.
DR RefSeq; XP_017572330.1; XM_017716841.1.
DR STRING; 42514.ENSPNAP00000037079; -.
DR Ensembl; ENSPNAT00000032618.1; ENSPNAP00000021381.1; ENSPNAG00000028429.1.
DR Ensembl; ENSPNAT00000040520.1; ENSPNAP00000037079.1; ENSPNAG00000028429.1.
DR Ensembl; ENSPNAT00000040527.1; ENSPNAP00000037084.1; ENSPNAG00000028429.1.
DR GeneID; 108438789; -.
DR CTD; 563298; -.
DR GeneTree; ENSGT00940000157097; -.
DR OMA; IHDMDTF; -.
DR OrthoDB; 3475284at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06965; NR_DBD_Ppar; 1.
DR CDD; cd06932; NR_LBD_PPAR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR003074; 1Cnucl_rcpt.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR003076; PPAR-alpha.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF197; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01288; PROXISOMEPAR.
DR PRINTS; PR01289; PROXISOMPAAR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 96..170
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 198..468
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 58..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 52709 MW; 016780F29F97E125 CRC64;
MVDVPNLFSP LSPVGDPVLD STLYGELIMN MEELEDISCS LNDDTLNLLY LPDCQGTSTS
PESSITLDVP SPASSPSSTV FEAVPGQDET TSSPLKLECR VCADRASGFH YGVHACEGCK
GFFRRTIRLK LEYDKCERSC KIQKKNRNKC QYCRFHKCLA VGMSHNAIRF GRMPRSEKLK
LKAELVGEME EGQTQLADLK TLARQLHEAY LRHFHLSKAK ARIFLAGKTS TPPFVIHDLD
TLQQAQQILA THMQGDEKDG LVSALQERET ESRLFRCCQH TSVETVTQLT EFAKAVPGFA
NLDLNDQVTL LKYGVHEAFF TLLASCMNKD GLLVAHGKGF ITREFLKSLR RPFSDLLEPK
FQFAMCFNAL QLDDSDLALF VAAIICCGDR PGLANVSHIE FIQESIIHAL QLHLQANHPD
NTFLFPKLLQ KLADLRQLVT EHAQLVQDIK KTQDTSLHPL LQEIYKDMY
//
