ID A0A3B4EPW2_PYGNA Unreviewed; 584 AA.
AC A0A3B4EPW2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Frizzled class receptor 8 {ECO:0000313|Ensembl:ENSPNAP00000037990.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000037990.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000037990.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR RefSeq; XP_017560320.1; XM_017704831.1.
DR AlphaFoldDB; A0A3B4EPW2; -.
DR STRING; 42514.ENSPNAP00000037990; -.
DR Ensembl; ENSPNAT00000034936.1; ENSPNAP00000037990.1; ENSPNAG00000030105.1.
DR GeneID; 108431579; -.
DR CTD; 58073; -.
DR GeneTree; ENSGT00940000161191; -.
DR OMA; DWEMTHN; -.
DR OrthoDB; 5483535at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0060898; P:eye field cell fate commitment involved in camera-type eye formation; IEA:Ensembl.
DR GO; GO:0021879; P:forebrain neuron differentiation; IEA:Ensembl.
DR GO; GO:0021529; P:spinal cord oligodendrocyte cell differentiation; IEA:Ensembl.
DR GO; GO:0021531; P:spinal cord radial glial cell differentiation; IEA:Ensembl.
DR CDD; cd15250; 7tmF_FZD8; 1.
DR CDD; cd07461; CRD_FZ8; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041776; FZ8_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF146; FRIZZLED 8A PROTEIN-RELATED; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..584
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017207770"
FT TRANSMEM 244..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..146
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 243..536
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 152..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..184
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 30..91
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 38..84
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 75..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 102..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 106..130
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 584 AA; 65806 MW; 42CDCB4D64521582 CRC64;
MECYLLGIYL FLALGALQRS SGTTAKELTC QEIAVPLCKG VGYNHTYMPN QFNHDTQDEA
GLEVHQFWPL VEIQCSPDLR FFLCSMYTPI CLEDYKKPLP PCRSVCERAR AGCAPLMRQY
GFPWPDRMRC DTLPVQGDPD TLCMDYNRTD STTASPVLSK PTGRPGKQHV PPHRTKHGHG
RPGVQTKRKP GSPCEPGCQC RAPMVRVSSE RHPLYNRVKT GQMPNCAMPC HNPYFTQDER
TFTAFWIGLW SVLCFVSTFA TVATFLIDME RFKYPERPII FLSACYMFVS IGYIVRLIAG
HEKVACSREY DVEHVHYETT GPALCTVVFL LIYFFGMASS IWWVILSLTW FLAAGMKWGN
EAIASYSQYF HLAAWLIPSM KSIAVLALSS VDGDPVAGIC YVGNQNLDNL RGFVLAPLVI
YLFIGTMFLL AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI GIFTVLYTVP ATIIVACYFY
EQHNRQSWET SHNCSCLMEH ELRRPDYAVF MLKYFMCLSV GITSGVWIWS GKTLDSWRAL
CTRCCWGSKG TSGSTYSDVS TGLTWRSGTA SSVSCPKQMP LSQV
//
