ID   A0A3B4EQL2_9CICH        Unreviewed;       839 AA.
AC   A0A3B4EQL2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000000280.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000000280.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR   AlphaFoldDB; A0A3B4EQL2; -.
DR   STRING; 303518.ENSPNYP00000000280; -.
DR   Ensembl; ENSPNYT00000000288.1; ENSPNYP00000000280.1; ENSPNYG00000000209.1.
DR   GeneTree; ENSGT00950000182815; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF4; NETRIN RECEPTOR UNC5A; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 1.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 1.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367033};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW   ECO:0000256|RuleBase:RU367033};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU367033};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU367033}.
FT   TRANSMEM        300..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT   DOMAIN          153..231
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          438..581
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   839 AA;  93557 MW;  592372A7DABFB123 CRC64;
     DEQRPGEGGR QEWGGREVST SAGSEHAATA TLPAAFSDLL PHFLVEPEDE YIVKNKPVTL
     TCRSTPATQI YFKCNGEWVH QDDHLIERTV DPATALPVMQ VTIEITRQQV EKIFGLDEYW
     CQCVAWSTTG TQKSQKAYIR IAYLRKNFEE EPQGKEVALD QEVLLRCHPP EGVPQAEVEW
     QRNEDVIDPA SDPNFVITPD HNLVIKKARL ADTGNYTCVA KNIVARRKST SAAILVYVDG
     GWSEWSKWSA CGADCSMWRS RECTQPSPGT GGKDCQGLDL QSLNCTSEQC PQTVSGAEDV
     ALYVGMVAVA LCLTLLLIVV VLVYRRKKEG LDADVADSSI LTTGFQPMGI KPSKPENSHL
     LTIQPDLTTT TTSYQGTLRS RHDATGKFSM TNGPLLDPLP NGSHTLHNGK LNSDAAAEFV
     SRLSTQSYFK TLPRDVANTS YGTFNFLGGR LTIPNTGISL LIPPEAIPRG KIYEIYLTVQ
     RKEDLRLPVA GCQTLLSPIV SCGPPGVVLS RPVILSMDHC FDACLDNWAV RLKKQNYEGA
     WEDVLLMGEE LVSDPYYCQL EAETCRLFSE QLGTFALVGE SLHMGAAKRL RLVLFSDAYC
     STLEYNIRVY CMDDTQDVFK EVMQMERQLG GRLIDEPHVL LFKDSYHNLR LSIHDMPQAH
     WRSKLLAGYQ EIPFYHIWNG SQRYLHCTFT LERLSLSTCE LTCQLCVWQV EGEGQSFSLD
     FNIAKDTRAL DSEFLLMDSN ATALAGPSAF QIPYLIRQKI CSSLDAPCPN GADWRMLAQR
     LKLERHMSFF ASKASPTSVI LDLWEAQHFH SGNINQLATV MADIGKQEAM IFLVSDGEC
//