ID A0A3B4ER23_9CICH Unreviewed; 286 AA.
AC A0A3B4ER23;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Stanniocalcin {ECO:0000256|ARBA:ARBA00017831, ECO:0000256|RuleBase:RU369112};
DE Short=STC {ECO:0000256|RuleBase:RU369112};
DE AltName: Full=Corpuscles of Stannius protein {ECO:0000256|RuleBase:RU369112};
GN Name=STC2 {ECO:0000313|Ensembl:ENSPNYP00000000228.1};
GN Synonyms=stc2 {ECO:0000313|RefSeq:XP_005719674.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000000228.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000000228.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005719674.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Has an anti-hypocalcemic action on calcium and phosphate
CC homeostasis. {ECO:0000256|ARBA:ARBA00037055}.
CC -!- FUNCTION: Its primary function is the prevention of hypercalcemia. Upon
CC release into the circulation, it lowers calcium transport by the gills,
CC thereby reducing its rate of influx from the environment into the
CC extracellular compartment. STC also stimulates phosphate reabsorption
CC by renal proximal tubules. The consequence of this action is increased
CC levels of plasma phosphate, which combines with excess calcium and
CC promotes its disposal into bone and scales.
CC {ECO:0000256|ARBA:ARBA00003962, ECO:0000256|RuleBase:RU369112}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748,
CC ECO:0000256|RuleBase:RU369112}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU369112}.
CC -!- SIMILARITY: Belongs to the stanniocalcin family.
CC {ECO:0000256|ARBA:ARBA00008693, ECO:0000256|RuleBase:RU369112}.
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DR RefSeq; XP_005719674.1; XM_005719617.1.
DR AlphaFoldDB; A0A3B4ER23; -.
DR Ensembl; ENSPNYT00000000235.1; ENSPNYP00000000228.1; ENSPNYG00000000177.1.
DR GeneID; 102203373; -.
DR CTD; 544665; -.
DR GeneTree; ENSGT00390000005989; -.
DR OrthoDB; 4573585at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR InterPro; IPR004978; Stanniocalcin.
DR PANTHER; PTHR11245; STANNIOCALCIN; 1.
DR PANTHER; PTHR11245:SF2; STANNIOCALCIN-2; 1.
DR Pfam; PF03298; Stanniocalcin; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|RuleBase:RU369112};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Secreted {ECO:0000256|RuleBase:RU369112}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..286
FT /note="Stanniocalcin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041124416"
FT REGION 213..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 286 AA; 31807 MW; A4034EC537C98E8F CRC64;
MFVNLAVLLL LVLSVLEQVV GTDNIDIYDT PPEKPASQKG RLSLQNTAEI QHCLVSAGDV
GCGVFECFEN NSCEIRGLQE ICMTFLHNAG KFDSQGKSFI KDALKCMAHG LRHKFGCISR
KCVSIKEMVF QLQRECYIKH NLCSAAKENV AVMVEMIHFQ DLFPKGPYVE LVNILLSCGE
EVKEALSRSV RLQCEQNWGA LCDSLSLCTS MAPSPASTPV ENRRQLMPSQ PEPEHPRLPR
QGEKERAGKA GFSSHPRNRS QGPRRHSPEA GVVAEEEDPK ATDIRR
//
