ID A0A3B4ET71_9CICH Unreviewed; 624 AA.
AC A0A3B4ET71;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Epsin-1-like {ECO:0000313|Ensembl:ENSPNYP00000001562.1, ECO:0000313|RefSeq:XP_005732029.1};
GN Name=LOC102212707 {ECO:0000313|RefSeq:XP_005732029.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000001562.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000001562.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005732029.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the epsin family.
CC {ECO:0000256|ARBA:ARBA00010130}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005732029.1; XM_005731972.1.
DR AlphaFoldDB; A0A3B4ET71; -.
DR Ensembl; ENSPNYT00000001596.1; ENSPNYP00000001562.1; ENSPNYG00000001256.1.
DR GeneID; 102212707; -.
DR CTD; 406671; -.
DR GeneTree; ENSGT00940000160411; -.
DR OrthoDB; 1532at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR CDD; cd16990; ENTH_Epsin; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR12276:SF48; EPSIN-1; 1.
DR PANTHER; PTHR12276; EPSIN/ENT-RELATED; 1.
DR Pfam; PF01417; ENTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00726; UIM; 2.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50330; UIM; 2.
PE 3: Inferred from homology;
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023}.
FT DOMAIN 12..144
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 148..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..353
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 64491 MW; CE13179D51048124 CRC64;
MSTSSLRRQV KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMV
WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVAQQCRENI YAVQTLKDFQ YIDRDGKDQG
VNVREKAKQL VTLLKDEERL REERIHALKT KEKMAQTSSA SSAPSAPSLG GSLSLGSHSG
GADSEQAWPQ SSGEEDLQLQ LALAMSKEEA EQEERLRRGD DLRLQMAIEE SKREKPKPEE
SALMELSAVD PWGTPAAPVV SSAGPSPLPT VSASAASGPW GTATTDPWGV ASPTSPTSSD
PWGGGAPPVI APPPDPWGES SNKVNNVDPW GSSAVTPPSA DPWGPPLPPS TSSSGGPVDP
WAKDGPVPAS DPITSDIWSG SAKHTNGTGD PEQLGSSGAG ADSTGSPVPF DLSSLGSSLP
VRKTPESFLG PNAALVDLDS LVPSKPKPKQ PPPPSISSSS AHNPFLQNTG SSPATGMAVT
PGSTISSRGV SPTPASSNPF GVAPPMTSIS PQPSSLGLSG LRTSPVPPNP MLGMVQPGMG
MVPMSMGMGA PGMGLGMMQP SPMSMPYSGL SPMAPPGSGL MGPGVAPPPQ LILGGPTGPG
GVMGAGGSVG GGGTTGTSTN PFLL
//
