ID A0A3B4EW71_9CICH Unreviewed; 1075 AA.
AC A0A3B4EW71;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Retinoblastoma-like protein 2 {ECO:0000313|Ensembl:ENSPNYP00000002400.1, ECO:0000313|RefSeq:XP_005745212.1};
GN Name=LOC102196756 {ECO:0000313|RefSeq:XP_005745212.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000002400.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000002400.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005745212.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR RefSeq; XP_005745212.1; XM_005745155.2.
DR AlphaFoldDB; A0A3B4EW71; -.
DR STRING; 303518.ENSPNYP00000002400; -.
DR Ensembl; ENSPNYT00000002463.1; ENSPNYP00000002400.1; ENSPNYG00000001845.1.
DR GeneID; 102196756; -.
DR CTD; 5934; -.
DR GeneTree; ENSGT00950000183202; -.
DR OrthoDB; 519973at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20606; CYCLIN_RBL2; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF8; RETINOBLASTOMA-LIKE PROTEIN 2; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 63..205
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 377..571
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 778..945
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 958..1075
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 589..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1075 AA; 118577 MW; 0C4FF662D6F82F4E CRC64;
MSDEDETAQR ARRGFEELCR ALNMDEEASG EAWGSYENIS RNFTLEGSEL HWLACALYVA
CRSSVPTVGK GTAEGNYVSL TRILRCSEMS LIEFFSKMKK WQDMADLPPD FRQSTDKLER
NFIVSAVIFK KYVPIFKSIF RAPSEEPPRV HRSRKQRRHP CTVTEVFNFC WVLFVHAKGN
FPMISDDLVN SYHLLLCALD LVFTNALLCN ARKDLLNPEF KGLPEDFGTK DFRPASGPFC
FMEQLCRLHD GLVLEAKGVK EHFWKPFIKK LFHKRILRGK EDSLTGFLDP MNFGDSLLAL
SRLYEEHVLA TGSLDERIFT GEGASEDIGT PGPCLCEGAE HQNSATFRLH TSLAASALKV
STPLTGRKYV QEGSLASPLS SAMKSVGRLH TLLSGTKQGP SAKLAETLRS CARDPSNAIS
RRLNDMFDVF SQHYEDGTTD GGRAMGKDMA VKYFHLAEAL YYRILESVIE REKMILGDAD
LSCILEQDIF HRSLLACCLE IVIFSYRPPG DFPNVLGIFQ LPAYHFYKVI EVLVRAEQGL
FREVVKHLNQ VEEQVLESLA WTGDSPLWES LRGAKDHAPS CQEVMPPQYL EQQDESSSGS
VPVTPVSHGA ELSSSSTLKG VSPSPTTLLD RYSSPPASTA RRRLFVDPVD SEPGLASSGS
ASTAVAKPTQ ASLVTAIPAG QTVVTMATAT VTANNGQTVT IPVQGIANES GGITFIPVQV
SVTGQAGAAL QPLPPQALAG TIAVQPATVK PAPKPAGGTL RKGSLSLFFR KVYHLASVRL
RDLCARLDIM PELRRKIWTC FEYSLVHCTD MMMDRHLDQL LMCAVYVMAK VTKEDRSFQN
IMKCYRSQPQ ASSNVYRSVL ISGRRRRHSS TNKPNPLTDG SQDAGGDVSP VPIRSSSTLP
TPQPGSAPST PTNTSNKTSC TSTANAGEDE QERGDLIHFY NNVYIKQMTP FALKYSPNSL
SAGVETPPLC PYPSVRTGSP RRMLLSSKHS IYISPHKAGS APSLMTPREK IHYYICSSPP
NRLQEINSMI RTGETPTRKR GMALEEGASP KRVCPDSNAL MRRLQDVAND RSSSQ
//
