ID A0A3B4EWK8_9CICH Unreviewed; 442 AA.
AC A0A3B4EWK8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons 2 {ECO:0000313|Ensembl:ENSPNYP00000002550.1};
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons protein 2 isoform X2 {ECO:0000313|RefSeq:XP_005733570.1};
GN Name=pacsin2 {ECO:0000313|RefSeq:XP_005733570.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000002550.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000002550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005733570.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR RefSeq; XP_005733570.1; XM_005733513.1.
DR AlphaFoldDB; A0A3B4EWK8; -.
DR Ensembl; ENSPNYT00000002617.1; ENSPNYP00000002550.1; ENSPNYG00000002019.1.
DR GeneID; 102201607; -.
DR CTD; 11252; -.
DR GeneTree; ENSGT00950000182973; -.
DR OrthoDB; 9421at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd11843; SH3_PACSIN; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF14; PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 2; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000313|RefSeq:XP_005733570.1};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|RefSeq:XP_005733570.1}.
FT DOMAIN 10..281
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 382..442
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 312..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 186..217
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 326..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 50970 MW; 1B67221771689A42 CRC64;
MSGTYDDSMI DVSSDSFWEV GNYKRTVKRI DDGSRLCTDL MNCIHERARI EKAYAQQLTE
WGKRWRQLVE KGPQYGTLER AWAALCTEAE KVSELHMEVK AALMGEDYEK LKNWQRESFH
KQMIGGFKET KETEDGFRKA QKPWAKKLKE VETLKKAYHT ACKEEKLAAS RETNSKLESN
NNPEAQKKLQ EKVEKCQQEV QKTKERYEKS IEELNKLTPQ YMENMEQVFE QCQQFEDKRI
QFFKEVLLEV KQHLDLSTNH RYQGVYHTLE DTISGTDPEE DLKWFRSNHG PGMPMSWPQF
EEWSIDLNRT LSRREKKKPS EGITLTGISP AGSDQPVQPA KTSNSASSTE KTPDWSDEDT
AGNPFSTNGE GNPFEEEPAS PVVSVPVKAL YDYEGQEQDE LSFKAGDEFT KIGEEDDQGW
CKGRLKDGQT GLYPANYVED IQ
//
