ID A0A3B4EWX7_9CICH Unreviewed; 4378 AA.
AC A0A3B4EWX7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Dynein axonemal heavy chain 2 {ECO:0000313|Ensembl:ENSPNYP00000001839.1};
GN Name=DNAH2 {ECO:0000313|Ensembl:ENSPNYP00000001839.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000001839.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000001839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 303518.ENSPNYP00000001839; -.
DR Ensembl; ENSPNYT00000001875.1; ENSPNYP00000001839.1; ENSPNYG00000001252.1.
DR GeneTree; ENSGT00940000157623; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF32; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1766..1902
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2373..2519
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2977..3068
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3180..3245
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4378 AA; 500885 MW; 14D8A83AD06C6A73 CRC64;
RVCRAQPQST WVPLATKGFQ GDEHTQLHVV AIINQLFLPT PLHILILFFS LSSKLFIDCV
AISGVTEESW TEENEKAVDQ FIEDASITTM VVYLDTKVGL RVEYSMPLLV VGQLSYFVRV
PEAIITLETF DTAIQFGTVQ GNPIQRLLQD MTCLHAPPVA ISAYREQSIK DSYTKHMHLY
LASLTDDVHK KFGNTVLYIP MEGLQCSAEE ASKDRKLIQR MEIVMIHWTD QIKELLNAQD
IVNMRDSCGP LQEISFWKTR STQLLNISRQ LQKPGVKHIQ NILQVAKSLY VQRFCQLAHE
IQDCSLQAQS NLTFLSILKE PCEELEQLKP SQIASKLKHI VSLIRIIWIN SPHYNTSERI
VNFFRQICDC QHQFARWEDG QQRALPCLGG CKGPGFTGTL LKNERDFHRS LEKLRSVDKG
ILDVKDTTWC NEFNRFCAFV KDLEMKIQGL IGSVFTTGNT VEEGIRLLDV FTPLFARKSI
KRTVEEKLEE TCNIFYKELK IGNKELNQTS MFYPDHMPRK AGQVYWVTAQ RHQLERFMEV
LQKAHLILDS QTCKELLTTC GQTMQILDEI VRKNFSEWTQ KLDVQYLKRL EQPLMVRCKD
KKLDINFDND LLNLFSEIQC WDRLKFEIPQ SVSDIYQDRD DLRGLRQQVL LLVREYNRIT
EMLSPEELGL FRERIRFIDK KIQPGLTKLL WLSKGASNIF IRDCLLHVDK VLHVIINNYK
VSSQSIFKHC HQISEALLIK LDGKTVYRNL EFEDDQKAHL QNILQILRSA HQDIVNIMTR
IYDILADDGP EVQEHWVNYI ERVDHMIEEA FNSNIKNSLK KLSRAINGDS KTTPSPLFKV
LVTLHSAVAF SPTLRKLAQV VNVMPQLISL ISEFKRLQEL LSNQESQKDP IHIIIGQDEG
IKKIQAAIAS GMTANASQLQ SHLKNWDKYR DIWEMNKDSI IQRYQRLNLP LSSFDADIQR
YSEKASSVQQ EETVLNIQFV MLDCSPLKSS LVQHCNEWQT KFTQLLSDMA SMRLKELHAS
LEDSASRLKK SPQTLTELSE SQKLLETLQS NLAKTEAQIP VIHEQFAILG KYEVPVEQDV
QEMRDVLNEE WVWFQQVLID SDIMLQKQKE KFKSSLLLSY EELKKTVEAT VEEFSAKGPF
NSALSTDLAL KQIAEHRSQL ETLKQEESTI LDGLRFFKIE QAPSKSIRTL EKDLDQLQQV
WDITEEWNGN WNIWKAGQFG TLQTESMETA AQDMFKKLHK LQRDLKDKQW DIVDFSKNRI
DQFRQVIPLI ADLRNPAIRD RHWKQISEEL QYSFDPTSVE FTLEKIISLG FNMYAGKICE
ISGAATKELS IEQGLKGITK TWKEMTLDIA PYKDEGHYRL RSTEEVFQAL EDNQVILSTM
KASRFVKAFE QEVDRWERQL SHVLEVTEMI LNVQRHWIYL ENIFQGKDIR EQLPHECKEF
EDISSSWKTI TGCLHKDKNA LQGTHKPGLP EKLSQMGFEL EEILKALDTY LETKRQIFPR
FYFLSNDDVL EILGQSQNPQ AMQPHLKKCF DNIKSLNRYK FSWLLKTLAA GMFSADGEFV
SLYEKVELNK PVEEWLCELE HSMRLSLKES LKDCLVDLKR ISGPRDKWVR AWPGQMIITA
SQIQWTADVT RALINCKERA DKAPLKSMKK KQVSMLQCYS EIIRGNLPKV LRLKIVALVT
VEVHARDVID KLAKAGCYDV SAFEWVSQLR LYWEKDQGNA MNCIIRQTNT EFNYGYEYLG
NSGRLVITPL TDRCYMTLTT ALHLHRGGSP KGPAGTGKTE TVKDLGKALG MYVIVVNCSE
GLDYKSMGRM YSGLAQTGAW GCFDEFNRIN IEVLSVVAQQ ILSILSALTA LQSKFYFEGQ
HIRLVSSCGI FITMNPGYAG RTELPDNLKS MFRPISMVVP DSTLIAEILL FGEGFNDCKL
LKVSYSTRDV YEEKTHLSQP QLRVLTYLLM LTVFLHKVQF ITDLRSVLLM AMKDMNIAKL
TSADLPLFSG IIQDLFPAVE TPVIDYGKLK EAVEEELNRS GLQVTPFTVT KVIQLYETKN
SRHSSMLVGK TGSAKSVTWR TLQNAMTALH QKGEPGFQQV QDYPLNPKAL SLGELYGEND
LSTNEWTDGV LSSLMRSACA DEKPDEKWIV FDGPVDTLWI ESMNSVMDDN KVLTLINGER
ISMPEQVSLL FEVENLAVAS PATVSRCGMV YNDYTDLGWK PFVQSWLNKR HKAEVNHLKP
LFEKYIESTI NYKKSNCKEL IPIAELNGVT SLCRLYDSLA TSSSGVNPSD TDSLGRMVEL
WFIFSLIWSI CASVDEDGRK RMDNFLREME GTFPAKDTVY DYYVDPKNKC WASFEDKLPK
GWRYNASAPF YKIMVPTVDT VRYNLLVKAL VLKHYPVLLT GPVGTGKTSV AQSILQGLDN
KWKTLTINMS SQTTSNNIQD IIESRIEKRT KGVYVPAGGK HLLCFLDDLN MPAHDLFGSQ
PPLELLRLWI DYGFWYDRKK QTLKVVKDMF LLASMGPPGG GRTRITPRFQ SRFNLINMTF
PNASQIKCIY SAMINQKLQE FKEELKPIGK LLTQATLELY NGVTAFFLPT PAKIHYLFNL
RDISKVFQGL LRAHPDFHDT KTNITRLWIH ECFRVFSDRL VNHSDMDTFI SLLEEKLGSL
FDFTFHSICP NKQLPIFVHY HESSVYEDLH DMKSLKKFME TQQEDYNLTP GVVPTNLVLF
RDAIEHITRI IRVISQLRGN MLVVGVGGSG RRSLSKIAAF ICQYQVFQVE VTKQYRKLEF
REDIKKLYRL AGVDNKPTVF LFNDTQIVDE SFLEDINNIL SSGEVPNLYK PDEFVEVCNA
LSESARKDNV AETPDSLFSY LIERVRNNLH IVLCLSPVGE PFRNRILQYP ALVNCTTIDW
FCEWPKDALL EVAERYLDGM ALGSVEGIQT KVASIFVTTH QSVAQVSQRM KLELRRQNYV
TPTNYLELVS GYKKLLAEKR GELGEQVSKL RNGLLKISET REKVEAMSLE LEEAKKQVAE
FQKQCDEYLS VIVQQKKEAD SQQKTVSDEN EKIGAEELQC KAMAENAQRD LDEALPALEE
AMKALESLNK KDMTEIKSYG RPPALVETVM HAVMTLLEKE PTWAEAKRQL GEGNFIKTLV
HFDKDNISDR VLKKIGLYCK QVDFQPEIIG KVSLAAKSLC MWVRAMEVYG RVYRVVEPKR
AQLNAAMAQL AEKQAALAEA QNKLRQLGEK LEQLKKQHSE KLAMKESLRK KSEEMEVKLD
RAGKLVTGLA GERVRWEERV VGLEENMGYL VGDCLLAASF LSYMGPFLSN YREELLQIWM
KEVSFAVFTS KPTVVRDWNI QGLPTDAFST ENGIIVTRGN RWPLMVDPQG QALKWIKKME
LSRGLKVIDF QMPDYLRVLE NAIQFGNPVL LQNVQEELDP SLNPILNKSL TCIGGRLLLK
LGDKEVEYSA EFRFYITTKL SNPHYTPEIS AMTTIVNFAV KEQGLEAQLL GIVVRKERPE
LEEQKDSLVI SIASGKKSLQ DLEDEILRLL NESTGSLLDD VQLVNTLQAS KVTATEVSKQ
LESSEQTELK IDSAREAYRP CAERASILFF ILSDMGRIDP MYQFSLDAYI NLFNLSIEKS
KRSQKLEERI TNLNDYHTYA VYKYTCRGLF EAHKLLFSFQ MCAKILEVAG KLNMDQYNFL
LRGGIVLDKK GQMDNPFTSW LADSSWDNIT QLDKLPGFRG IVSSFEQSSR DWNVWFTSSE
PENAPLPGDW ESKCNEFQKM LIVRAMRPDR VSFCITSFII KHLGSRFVEP PVLDMKSVVE
ESTSCTPLIF VLSPGVDPTG ALLQLAEASG MSNHFQALSL GQGQAPIAKS MIEEGIKNGH
WVFLANCHLS LSWMPELDKL IKQLQLQKPH PDFRLWLSSS PHPDFPITIL QAGIKMTTEP
PKGVKANMKR LYQLVTEAQF NSCNKPAFYR KLLFSLCFFH SILLERKKFL QMGWNIVYGF
NDSDFEVSEK LLSLYLNDYE EIPWDALKYL IAGVNYGGHV TDDWDRRLLT TYINDYFCDA
VINQPFFKLS TLTNYYIPRD GSQALYKEYI DRMPSTEHPE LFGQHSNADI ASQIAETKTV
FDTLLSLQPQ VTSKTAAGGS REDKVLELLT DVRVKIPKYI ECEGTRTLLL DNPSPLNVVL
LQEIQRYNSL LSTIKSSLVE LEKGIKGLVV MSPSLEEIFN CIHDARVPSL WEKAYPSLKP
LAAWTRDLCQ RVDQFARWAQ TTQPPNLFWL SGFTFPNGFL TAVLQSSARQ RNISVDMLSW
EFIVSTVDDS KLLYPPKDGV FVRGLYLEGA GWDKNNSCLV EAKPMQMVCP IPTIHFKPVE
NRKKMAKSTY LCPCYYYPVR AGGAGRASFV VGVELKSGAV TPEHWIKRGT ALLMSLDN
//
