ID A0A3B4EZX9_9CICH Unreviewed; 817 AA.
AC A0A3B4EZX9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Receptor-type tyrosine-protein phosphatase alpha {ECO:0000256|PIRNR:PIRNR002006};
DE EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR002006};
GN Name=ptpra {ECO:0000313|RefSeq:XP_005731290.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000003780.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000003780.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005731290.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|PIRNR:PIRNR002006};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 4 subfamily. {ECO:0000256|ARBA:ARBA00007765,
CC ECO:0000256|PIRNR:PIRNR002006}.
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DR RefSeq; XP_005731290.1; XM_005731233.1.
DR AlphaFoldDB; A0A3B4EZX9; -.
DR STRING; 303518.ENSPNYP00000003780; -.
DR Ensembl; ENSPNYT00000003876.1; ENSPNYP00000003780.1; ENSPNYG00000002948.1.
DR GeneID; 102195203; -.
DR CTD; 5786; -.
DR GeneTree; ENSGT00940000159585; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IEA:Ensembl.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR CDD; cd14621; R-PTPc-A-1; 1.
DR CDD; cd14623; R-PTPc-A-2; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR016336; Tyr_Pase_rcpt_a/e-type.
DR InterPro; IPR027262; Tyr_Pase_rcpt_alpha.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF433; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ALPHA; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PIRSF; PIRSF500808; PTPR_alpha; 1.
DR PIRSF; PIRSF002006; PTPR_alpha_epsilon; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR002006};
KW Membrane {ECO:0000256|PIRNR:PIRNR002006};
KW Phosphoprotein {ECO:0000256|PIRSR:PIRSR002006-3};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR002006};
KW Receptor {ECO:0000313|RefSeq:XP_005731290.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Signal {ECO:0000256|PIRNR:PIRNR002006};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR002006};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR002006}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT CHAIN 19..817
FT /note="Receptor-type tyrosine-protein phosphatase alpha"
FT /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT /id="PRO_5041500370"
FT TRANSMEM 167..190
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR002006"
FT DOMAIN 256..516
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 436..507
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 548..806
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 722..797
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 31..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..126
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 457
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT ACT_SITE 747
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-1"
FT BINDING 425
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT BINDING 457..463
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT BINDING 501
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-2"
FT MOD_RES 813
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000256|PIRSR:PIRSR002006-3"
SQ SEQUENCE 817 AA; 91203 MW; 3D78264EEFC5FF97 CRC64;
MGVCALLLLL GVALGGSAED LAPVTGPPDI TTIPTKPSTA PSLKDGVPVS NPTHPPTKLA
QAIITSAAIT TKTTTTTTTT KAAEAAATTD TSLDSNQDTE LNSSTPTVQL ASPPTPQAPP
SINPPLTPSI SEGDDETSAT SPETATTPTT TTTSTPNSDE DAGDMPIIAV MVALSSLLVI
IFIIIILYML RFKKYKQAGS HSNSFRLTNG RSDDTELQSV PLLARSPSTN RKYPPLPVDK
LEEEMNRRMA DDNKLFREEF NALPVCPIQA TCDAASKEEN KEKNRYVNIL PYDHSRVHLS
SLEGVPDSDF INASFINGYQ EKNKFIAAQG PKEETVNDFW RMIWEQNTVT IVMVTNLKER
KECKCAQYWP DQGCWTYGNI RVSVEDTMVL VDYTIRKFCI QQVGDVSGKK PQRLITQFHF
TSWPDFGVPF TPIGMLKFLK KVKACNPQYA GPIVVHCSAG VGRTGTFIVI DAMLDMMIAE
KKVDVFGFVT RIRAQRCQMV QTDMQYVFIF QALLEHYLYG DTELEVTSLE SHLAKLYAPS
PGAGCSGLEA EFKKLTSIKI QNDKMRTGNL PVNMKKNRVL QIIPYEFNRV IIPVKRGEEN
TDYVNASFID GYRQKDAYMA SQGPLQHTIE DFWRMIWEWR SCSIVMLTEL EERGQEKCAQ
YWPSDSAVTH GDITIELKRE EENESYTVRD LLVTNIRENK TRVVRQFHFH GWPEVGIPTD
GKGMINLIAA VQRQQQQSGN HPITVHCSAG AGRTGTFCAL STVLERVKAE GILDVFQTVK
SLRLQRPHMV QTLEQYEFCY KVVQEYIDAF SDYANFK
//
