ID   A0A3B4F0S4_9CICH        Unreviewed;      1034 AA.
AC   A0A3B4F0S4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Multiple EGF like domains 11 {ECO:0000313|Ensembl:ENSPNYP00000002826.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000002826.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000002826.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   AlphaFoldDB; A0A3B4F0S4; -.
DR   STRING; 303518.ENSPNYP00000002826; -.
DR   Ensembl; ENSPNYT00000002900.1; ENSPNYP00000002826.1; ENSPNYG00000002097.1.
DR   GeneTree; ENSGT00940000155333; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   Gene3D; 2.10.25.10; Laminin; 2.
DR   Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 4.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR011489; EMI_domain.
DR   InterPro; IPR002049; LE_dom.
DR   InterPro; IPR042635; MEGF10/SREC1/2-like.
DR   PANTHER; PTHR24043:SF7; MULTIPLE EGF LIKE DOMAINS 11; 1.
DR   PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR   Pfam; PF12661; hEGF; 3.
DR   Pfam; PF00053; Laminin_EGF; 2.
DR   PRINTS; PR00011; EGFLAMININ.
DR   SMART; SM00181; EGF; 14.
DR   SMART; SM00180; EGF_Lam; 9.
DR   PROSITE; PS00022; EGF_1; 7.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS51041; EMI; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        773..794
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          41..111
FT                   /note="EMI"
FT                   /evidence="ECO:0000259|PROSITE:PS51041"
FT   DOMAIN          172..207
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          629..659
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          991..1034
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1010..1034
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        197..206
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        649..658
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   1034 AA;  111209 MW;  BC930ABFD6EB9004 CRC64;
     MFAVNTKTYF NILHLIFVYS IMTQVYPELE IHPVKLFFPC SSSYAVTVQE SYAHPFDQVY
     YTRCTDILNW FKCTRHRISY KTAYRRGVRT MYRRRSQCCP GFYESGELCV PLCTEECAHG
     RCVSPDTCQC EPGWGGLDCS SGEYSADKQT CRCPAGFRSH PGCEEPCPPG KHGPLCEHHC
     PCQNGGTCHH VTGECSCPAG WMGPVCAQPC PFGSFGINCS QECTCRNGGL CDHISGECTC
     AAGWTGCQDE CPVGTYGPQC AHKCDCQNRA KCYHINGACL CNEGFKGPSC QDRFCPTGLY
     GLICDKYCPC IHTNTLSCHP LSGECTCAAG WTGLYCDETC PPGYYGEGCR ELCVCANGAY
     CDGITGACIC APGYIGDDCS ISCLAGLYGI NCSSSCSCQN EISCSHTDGS CICREAGWQG
     VDCSIPCSSG TWGLSCNQTC QCANGAACNP VSGTCACSPG WMDEYCDVPC PDGSYGLDCR
     EKCDCVNSDG CDPVTGVCRC LAGWTAFDNC DIICAFLVAY CHNVDFSSTA CSPGFYGHRC
     SLMCPQCVHS DGACHHITGH CKCLAGFFGS LCNEVCPSGK FGKACAETCL CTNNGTCNPI
     DGSCQCYPGW TSEDCSKPCP WGSWGLDCIH TCTCHNGAQC SATDGECICS PGWTGLYCTQ
     RCPAGFYGSH CAEVCRCQNG ADCDHITGQC SCRTGFIGHS CELKCPAGTF GYGCQQLCEC
     MNNATCDYVT GTCYCSIGFK GIRCDQAALM MEELNPYTKM SPALASQRQS TGAVLGIVFL
     LLMIMAMLAL VVWFRYRQRE KGHRVPSVTY TPALNISSTD YSLSGTISVS LGGCFSNPSY
     RTLGSCTYAT HYAKPDKRSF AKVGSKTFYI LPSESFKSLF NEGLNTLCLT LSLDYVKSSL
     SSTCSLNSEN PYATITDNPS LCKHSESSYV EMKSPAHHEH TAHCCSAAII SATTTTTVPA
     KNVYNMEPTI SIVPASGAAV VPSYPQNPYD LPRNSHIPSH YDLLPMRPSP SHSHSLTLNS
     CSPPLPGSPT SSLL
//