ID A0A3B4F1Q1_9CICH Unreviewed; 754 AA.
AC A0A3B4F1Q1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Ligand of Numb protein X 2 isoform X2 {ECO:0000313|RefSeq:XP_005722700.1};
DE SubName: Full=Ligand of numb-protein X 2 {ECO:0000313|Ensembl:ENSPNYP00000004445.1};
GN Name=lnx2 {ECO:0000313|RefSeq:XP_005722700.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000004445.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000004445.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005722700.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005722700.1; XM_005722643.2.
DR AlphaFoldDB; A0A3B4F1Q1; -.
DR STRING; 303518.ENSPNYP00000004445; -.
DR Ensembl; ENSPNYT00000004557.1; ENSPNYP00000004445.1; ENSPNYG00000003429.1.
DR GeneID; 102212467; -.
DR CTD; 553331; -.
DR GeneTree; ENSGT00940000158381; -.
DR OrthoDB; 3028121at2759; -.
DR Proteomes; UP000261460; Unplaced.
DR Proteomes; UP000695023; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR CDD; cd16780; mRING-HC-C3HC3D_LNX2; 1.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR19964:SF33; LIGAND OF NUMB PROTEIN X 2; 1.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000695023};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 49..87
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 274..359
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 395..478
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 534..620
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 664..750
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 138..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 754 AA; 81988 MW; D5E8EFAAA4C2D670 CRC64;
MGSPGSEVGL AGSVEPALEA LCPECGQIHR SWENHLYNYR LEVDDDLVCH ICLQPLVQPL
DTPCGHTFCA RCLRSFLQER DFCPLDRTRL QLQACRRSSI LVHKLLDKLS VSCPLTPVCS
LSMPRCDLEA HLKHRCPGMQ SQQTNGDGPR CESGDERAMV TSPPRSPHTP QTDLRDRTPS
PPSGPNNSCG NGPVWTDDAG LDNPAFEEST EEDSVVGLEC VVPRVKRPLS NPCIHLLRSV
SSTSSGWDCP ESPPLSAEEG CVKLPSLPEG EITAIEVHRA NPYVELGISI VGGNETPLIN
IVIQEVYRDG VIARDGRLLA GDQILQVNNV DISNVPHSFA RSTLARPCTT LQLTVLRERR
CASRAPPSSS SSTPAVPHAP CSTPEVTPPS PATLRITLHK RDSTEQLGIK LVRRTDESGV
FVLDLLEGGL AAKDGRLRSN DRVLAVNEQD LRHGTPEQAA QIIQASGERV HLLIGRPSKP
TPPPPPKSSS TRDLYCLDHF LPNHSSTPSP VAIHLSRTST HRDLSQCVTC KEKHITVKKE
PHESLGMTVA GGRGSKSGEL PIFVTSVQPH GCLSRDGRIK RGDVLLSING QDLTYLSHSE
AVGTLKASAA SPSVQLRVLE VSMVEEQDHD ELLPHTHDSD FDANWSPSWV MWLGLPSYLH
SSHEIVLRRS HPGSWGFSIV GGYEESHGNQ AFFIKTIVLG TPAYYDGRLK CGDMIVAVNG
LSTAGMSHSA LVPMLKEQRS RVALTVVSWP GSLV
//
