ID   A0A3B4F1Z9_9CICH        Unreviewed;      1396 AA.
AC   A0A3B4F1Z9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=SAM domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000003221.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000003221.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 303518.ENSPNYP00000003221; -.
DR   Ensembl; ENSPNYT00000003306.1; ENSPNYP00000003221.1; ENSPNYG00000002515.1.
DR   GeneTree; ENSGT00390000013973; -.
DR   Proteomes; UP000261460; Unplaced.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   PANTHER; PTHR16155; DED DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR16155:SF18; STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 9-LIKE; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
FT   DOMAIN          15..61
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          99..192
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   REGION          939..961
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          978..999
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        941..959
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1396 AA;  162610 MW;  ACDB1B2501FF1BEC CRC64;
     MAKHQSEFPE YVEKWTKEQV SQWLMQHVNV YSKYAERLQE EDVSGDCLVC FRKQDLVDLD
     VKGGPAVRII SLYTNENEKI KINKAVGFLN IAFFQQTTVS PDASRITVEI KNILDDLLKV
     DLKTFIFRLR LHTESKRKPI CQSKLEDKDS MDIAKLMTDH YGSKEAPQVA IQTLKEINQL
     KLACQLEERI SQLMQMTLSK ESVRKEANQG EKLKTLLSCG GNSLDNYDKF VVVVNKSNPE
     QLHYLQFLTK LKLFCVLDFD HSSAASGGLC HSYRESRWAN QHTPPQFQGQ TESVIKNLNL
     YKQTSWVFCN GRHDLNSDSN LALDYKNWLR KSCKDVEQLV SFICNPEVLL RGRYLIIFLL
     LSPVDTEKDP VFDIYKAFIK HTEEENIISV CESQSTYLKW RELIKEKCDS DIEHLSINEL
     TLSEINGTIM TMGPFSQSSV RLLPSSGSST VVLTQKDEDL LTALDVLCTN QCESVDDENS
     SEFHEFRKSV EKEFYRGGKV KWWNFYFCHK DKEKPFIKRD KYENVMKLIR SQWRDSNDMC
     VLLNLFHHPG CGGTTLAMHV MWDLRHEFRC AVLKDNSMPK TEVAIQVIKL MKLESEKPSP
     VLLLVDSKET DNPYDLVISI RKAAVEENFS VSADDAPNWK VIILNCVRSH SPKQQYRQHN
     QTQNQFITAS LTPQEQKDFE KKLKELEETH DKPENFYSFM IMKNNFDQKY IDDLAHNTLE
     NFDFSKKESE LFAFLALLNT YVEESEISLS LCEDFLGMKF IRWREDSVLE RMNPYSNLLI
     IDRIQESGGY EGLRILHQTI ASACLAELER SCYKKVSEIT MQMLHYDLFF STFVVKNRLM
     RSIERMLIER QRKKDGDERE LFSPLVHKIH NQQGRQTIQE IFVKASSRFV TSASIPQALA
     RYLYINERDF PEALKWAEKA KDIKENPYTF DTIGQIHKSN LKSNMDREKQ EKSHNPEDLD
     TNIKIAINGM KAFERAQQLA DKEDEPQEEP PDDDSEDYPR KSYNVYGYVR MLEIAFLVFE
     ILSKLPFFDE HNPMKKKYLQ SFLRGNKLNT LCDEDNEITN WYVKIINEHE RFLVKLKSDV
     KEIFDILNCY FAYIKGVCKF DSMNHQIVCD HFKKYVHLFC STPEEMTKEK EHQSNLTLKL
     DVQEQKLFLE KNQADTFSGI LQHLDKPAEK IEMVTECYAF LQKTGNQKQN SQMKINYILS
     NIVLYFLKPK SKHVKSYRFL SGLLSETLQE IGLCYHLPDP YYLALLLFWP SPTEENTEIG
     KYVTAIRKSS HKYLSKLFNK RSTIARLYLG KGEGLKRLVS KPKLDESFLP KMPRDTLAQL
     WWNGDIFKEK AIISRLHRVS GTIEQGAVYA NYGQQKILVR PARLSGIRSG FSTEKVSFYI
     GFAINGPLAY DIKYEN
//