ID A0A3B4F219_9CICH Unreviewed; 1820 AA.
AC A0A3B4F219;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=ADP ribosylation factor guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSPNYP00000003241.1};
GN Name=ARFGEF1 {ECO:0000313|Ensembl:ENSPNYP00000003241.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000003241.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000003241.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}.
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DR STRING; 303518.ENSPNYP00000003241; -.
DR Ensembl; ENSPNYT00000003326.1; ENSPNYP00000003241.1; ENSPNYG00000002399.1.
DR GeneTree; ENSGT00940000157108; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF137; BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 660..849
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 46..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1521..1555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1800..1820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1521..1554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1820 AA; 205106 MW; 28EF94DC351F4534 CRC64;
MFEGKKTKNM FLTRALEKIL ADKEVKKAHH SQLRKACEVA LEEIKEESEK LSPPGGDGKS
GSSTLPPIKS KTNFIEADKY FLPFELACQS KCPRIVITSL DCLQKLIAYG HLTGSAPDST
APGKKLIDRI IETICACFQG PQTDEGVQLQ IIKALLTAVT SQHIEIHEGT VLQAVRTCYN
IYLASKNLIN QTTAKATLTQ MLNVIFARME NQALQEAKQL ERERHRQHSP VTQHTEPDSA
QHQTHIHSEQ EEKGENPDPE NGSEFCVAES EQTEADQATA AAESKAARHC LDPANLCSDT
KESGGEGEPA ESEPAEAATE GTQSSLEDEG TVGSDSEHVH ANGIPGTPIS ASFTPSLPDD
RLSVSSNDTQ ESGAAPGQPP GAKFSHILQK DAFLVFRSLC KLSMKPLSDG PPDPKSHELR
SKVLSLQLLL SILQNAGPIF KTNEMFINAI KQYLCVALSK NGVSSVPEVF ELSLSIFLTL
LSHFKTHLKM QIEVFFKEIF LYILETSTSS YDHKWMVIQT LTRICADAQS VVDIYVNYDC
DLNAANIFER LVNDLSKIAQ GRGGHELGIT PQQELTLRKK GLECLVSILK CMVEWSKDQY
VNPNSQTSLG QEKPSEQEST ESKAPETINR YGSINSLDST ASSGIGSYST QMSGTDNPEQ
FEVLKQQKEI IEQGIDLFNK KPKRGIQYLQ EQGMLGTTPE DLAQFLHQEE RLDSTQVGEF
LGDNDRFNKE VMYAYVDQMD FQGKDFVSAL RMFLEGFRLP GEAQKIDRLM EKFAARYLEC
NQGQTLFASA DTAYVLAYSI IMLTTDLHSP QVKNKMTKEQ YIKMNRGIND SKDLPEEYLS
AIYDEIAGKK IAMKETKELT MKSNKQSVAS EKQRRLLYNL EMEQMAKTAK ALMEAVSHVQ
APFTSATHLE HVRPMFKLAW TPFLAAFSVG LQDCDDTEVA SLCLEGIRCA IRIACIFSIQ
LERDAYVQAL ARFTLLTASS GIAEMKQKNI DTIKTLITVA HTDGNYLGNS WHEILKCISQ
LELAQLIGTG VKARYISGTV RGKEGFIAST KEQSSDEYLG LVGGTVDRKQ IASIQESIGE
TSSQSVVVAV DRIFTGSTRL DGNAIVDFVR WLCAVSMDEL ASPTHPRMFS LQKIVEISYY
NMGRIRLQWS RIWEVIGDHF NKVGCNPNED VAIFAVDSLR QLSMKFLEKG ELANFRFQKD
FLRPFEHIMK KNRSPTIRDM VVRCIAQMVN SQAANIRSGW KNIFSVFHLA ASDQDESIVE
LAFQTTGHIV TNVFEKHFAA TIDSFQDAVK CLSEFACNAS FPDTSMEAIR LIRHCAKYVS
DRPQAFKDYT SDDMNVAPED RVWVRGWFPI LFELSCIINR CKLDVRTRGL TVMFEVMKTY
GHTFEKHWWQ DLFRIVFRIF DNMKLPEQQT EKAEWMTTTC NHALYAICDV FTQYFESLNG
VLLDDILAQL YWCVQQDNEQ LARSGTNCLE NVVILNGEKF SPETWDKTCN CMLDIFKTTI
PHYLCLLCSQ DSVSQKSLDI QSRSDDQHSI SSSDRAAMEN RRQSQYSSAS GVTEDGPRKI
QEQRLFSALL IKCVVQLELI QTIDNIVFFP ATSKKEDAEN FAAAQRDAVC SADVSVETQD
QGMYRYLTSE QLFKLLDCLL DSHHFAKAFN SNNEFDRQKL ENFNMLSFKG KSKPNLLKQE
TSSLACGLRI LFRMYTDESR RDAWEEVQRR LLNVCSEAVA YFLALTSESH REAWTNLLLL
FLTKVLKIND ERFKAHASRY YPLLCEIMQF DLIPELRAIL RKFYLRIGIV FNIAQLPEPQ
QAREPETDME VGEEAGEEAQ
//
