ID   A0A3B4F2H5_9CICH        Unreviewed;       885 AA.
AC   A0A3B4F2H5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE            EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
GN   Name=DPP9 {ECO:0000313|Ensembl:ENSPNYP00000004153.1};
GN   Synonyms=LOC102213980 {ECO:0000313|RefSeq:XP_005721108.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000004153.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000004153.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_005721108.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC         polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC         Pro nor hydroxyproline.; EC=3.4.14.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001257};
CC   -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC       {ECO:0000256|ARBA:ARBA00010036}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_005721108.1; XM_005721051.2.
DR   AlphaFoldDB; A0A3B4F2H5; -.
DR   STRING; 303518.ENSPNYP00000004153; -.
DR   Ensembl; ENSPNYT00000004258.1; ENSPNYP00000004153.1; ENSPNYG00000003193.1.
DR   GeneID; 102213980; -.
DR   GeneTree; ENSGT00940000158174; -.
DR   OrthoDB; 170111at2759; -.
DR   Proteomes; UP000261460; Unplaced.
DR   Proteomes; UP000695023; Unplaced.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR045785; Dpp_8/9_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF19520; Dpp_8_9_N; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000695023}.
FT   DOMAIN          35..158
FT                   /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19520"
FT   DOMAIN          174..592
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          685..885
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   885 AA;  101014 MW;  C4D18D6DF1F52B28 CRC64;
     MHRVKKVRLC DNKDGIWTSC VTVSMTAVDG LSDNAEVVEM EDVPSQFFVE KHSWEGLRDI
     IHCSRKYSGM IANKAPHDFQ FVQKNDENGP HSHRLYYLGM PYGSRENSLL YSEIPKKIRK
     EALLVLSWKQ MLDHFQATPH QGAYSREEEL LRERKRLGAF GITSYDYHSQ TGLFLFQASN
     SLFYCQDGGN NGFIQSAPVK PMEIKTQCSG TRMDPKICPG DPDFIAFINN NDLWIANIKT
     GEERRLTYCH KGLDNVKEDP KSAGVATFVI QEEFDRFTGY WWSPTAVEDP NGGKTVYLLY
     EEVDETEVEI IHVPSPALEE RKADAYRYPR TGSKNPQSTL KLAEIKTDHQ GRIVSTHDKE
     LVAPFNSLFP GTEYIARVGW TSDGKYGWAV LLDRSQRKLQ LVLLPPALFI PVTDDPALRQ
     ESLEAVPTNT QPYIIYEETT DVWINVHDIF YPFIQTTEDE FTFIWVNESK TGFSHLYKIT
     SQLQPGCYRW IEEYQHLEGD FKCAIKEEVT LTCGEWEVLA RHGSKIWVNE ATKLVYFQGT
     RDTPLEHHLY VVSYESPGDV VRLTKPGFSH SCSVSQNFDF FVSHYSNVST PPCVHVYKLT
     GSEGDPLHMV PEFWASMMES PGCPGDYNPP EIFDFPGKSG FQLYGMVYKP HNLQSGRKHP
     TVLFVYGGPQ VQLVNNSFKG MKYLRLNTLA SLGYAVVVID GRGSCQRGLE FEGALKNKMG
     QVEIEDQVEG LQYVAEKFNF VDLSRVAIHG WSYGGFLSLM GLIQRPNVFK LAIAGAPVTV
     WMAYDTGYTE RYMDVPENNQ QGYEEGSVAL HVDKLPSEPN RLLILHGFLD ENVHFFHTNF
     LVSQIIRAGK PYQLQVYPNE RHSIRCPESG EHYEIMLLHF LQQYL
//