ID A0A3B4F4B4_9CICH Unreviewed; 737 AA.
AC A0A3B4F4B4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Axin-2-like {ECO:0000313|Ensembl:ENSPNYP00000005397.1};
GN Name=AXIN2 {ECO:0000313|Ensembl:ENSPNYP00000005397.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000005397.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000005397.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A3B4F4B4; -.
DR STRING; 303518.ENSPNYP00000005397; -.
DR Ensembl; ENSPNYT00000005538.1; ENSPNYP00000005397.1; ENSPNYG00000004181.1.
DR GeneTree; ENSGT00940000157338; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd11582; Axin_TNKS_binding; 1.
DR CDD; cd08707; RGS_Axin; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR043581; Axin-like.
DR InterPro; IPR014936; Axin_b-cat-bd.
DR InterPro; IPR032101; Axin_TNKS-bd.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46102; AXIN; 1.
DR PANTHER; PTHR46102:SF1; AXIN-2; 1.
DR Pfam; PF16646; AXIN1_TNKS_BD; 1.
DR Pfam; PF08833; Axin_b-cat_bind; 1.
DR Pfam; PF00778; DIX; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00021; DAX; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 86..205
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 655..737
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 81696 MW; 53F598F05DC151DD CRC64;
MSRALTEHIS SSFREDAPRP PVPGEEGEAS CYNPSRSAKM RAQSKVKDIP AASAPPGSTP
RRNEDGLGEP EGSASPDSPL VRWTKSLHFL LGDQDGAHLF KTFLERENCV DTLDFWFACN
GFRQMDLKDT KTLRVAKVIF KRYIENNSIV AKQLKPATKA FIRDSIKKQQ IDSSMFDQAQ
TEIQSNMEEN AYQMFLTSDI YLEYVRTGCE NAAYMNHGGL GSLKLMCGYL PPLMEEEEWS
CNDLKAKTLG SVVGLSAKNL RATATIRTAA EVLENSCRSH RRGDPASPYF VNSGYIFAPA
TSANDSEISS DATTDDSMSM TDSSVDGIPP YKLGTKKQLQ REMHRSVKIN GQVTLPHFPR
THRLPKEMTP VEPSAFAAQL IARLEKLKRE QETMSSLEER LQQIQEEEER EEGNDLISST
SLQHPLLPSA SQCEEDPQAI LDEHLSRVLK TPGCQSPGVV RHSPRSRSPD RTGAVVSSGH
GPFFGAYPGA SKVLMTGRQS TKHIHHHYIH HHHAGPKTKE QIEAEAAQRV QCLCPQGGAN
YSDFTPATQG LKKSNPLDSK TLPGRTSSSW GGGGIGNGAH LRGHHPGHPF IQDPAMPPLP
PPNTLAQLEE ACRRLEEVSK PPKQSNLQRD RNHPAAVFPT GSNSLASPGV QADESKELVV
TYFFCGEEIP YRSMMKTHCL TLGHFKEQLS KKGNYRYYFK KASDEFECGA VFEEVWEDAT
VLPMYEGKVL GKVERMD
//
