UniProt: A0A3B4F5P7

Database: UniProt
Entry: A0A3B4F5P7_9CICH

LinkDB:  A0A3B4F5P7_9CICH 
Original site:  A0A3B4F5P7_9CICH

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Ontology (4)   
   GO (4)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (25)   
   InterPro (14)   
   Pfam (7)   
   PROSITE (1)   
   SMART (3)   
All databases (32)   

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ID   A0A3B4F5P7_9CICH        Unreviewed;      1899 AA.
AC   A0A3B4F5P7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Plexin-A2-like {ECO:0000313|Ensembl:ENSPNYP00000005258.1};
GN   Name=PLXNA2 {ECO:0000313|Ensembl:ENSPNYP00000005258.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000005258.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000005258.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC   -!- SIMILARITY: Belongs to the plexin family.
CC       {ECO:0000256|ARBA:ARBA00010297}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   STRING; 303518.ENSPNYP00000005258; -.
DR   Ensembl; ENSPNYT00000005395.1; ENSPNYP00000005258.1; ENSPNYG00000004023.1.
DR   GeneTree; ENSGT01050000244850; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR   GO; GO:0003403; P:optic vesicle formation; IEA:Ensembl.
DR   CDD; cd00603; IPT_PCSR; 1.
DR   CDD; cd01180; IPT_plexin_repeat1; 1.
DR   CDD; cd01179; IPT_plexin_repeat2; 1.
DR   CDD; cd01181; IPT_plexin_repeat3; 1.
DR   CDD; cd12790; RasGAP_plexin_A; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR031148; Plexin.
DR   InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR   InterPro; IPR046800; Plexin_RBD.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR041019; TIG1_plexin.
DR   InterPro; IPR041362; TIG2_plexin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR22625; PLEXIN; 1.
DR   PANTHER; PTHR22625:SF37; PLEXIN-A2; 1.
DR   Pfam; PF08337; Plexin_cytopl; 1.
DR   Pfam; PF20170; Plexin_RBD; 1.
DR   Pfam; PF01437; PSI; 3.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 4.
DR   Pfam; PF18020; TIG_2; 1.
DR   Pfam; PF17960; TIG_plexin; 1.
DR   SMART; SM00429; IPT; 4.
DR   SMART; SM00423; PSI; 3.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF81296; E set domains; 4.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 2.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1243..1265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          21..512
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
FT   COILED          1269..1296
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1899 AA;  211871 MW;  AAC46185252E4767 CRC64;
     MEGQQAFRRT LSLNPKVGPM AALLGFWLIV IPALSNGQTF TSFHPERRDW VFNHLTVHQT
     TGALYIGAVN RVYKLSGNLT LLVSHDTGPE DDNKACYPPL IVQPCSEPLV STNNVNKLLL
     IDYSQNRLLA CGSLYQGVCK LLRLDDLFIL VEPSHKKEHY LSSVNQTGTM YGVIVPSQGQ
     DGTLFIGTAV DGKQDYFPTI SSRKLPRDPE SSAMLDYELH TDFVSSLIKI PSDTLALVSH
     FDIYYVYGFA SGSFVYFLTV QPETPENSMS SSGSGSDLFY TSRIVRLCKD DPKFHSYVSL
     PIGCVKSGVE YRLLQAAYLG KPGRVLAASL NISAHDDVLF TIFSKGQKQF HRPPDDSALC
     VFTIRDINAR IKERLQSCYQ GEGNLELNWL LGKDVQCTKA PVPIDDSFCG LDINQPLGGS
     QLVTGHTLYT ETRDRMTSVT SYVYNGYCVA FVGTKSGRLK KIRVDGPPHG GVQYETISVI
     KDGSPVLRDM AFSLDRNYLY VMSERQVTQV PIESCEQYGT CGECLSSGDP HCGWCVLHNI
     CSQRNRCERA DEPYRFAASL NQCVKATVYP DSIAVSEPSL LVKVSDVPDL SAGITCSFGN
     LTEVEGQVNG NQILCKSPAA KDVPLIPTDQ DWSGVELRLN SKETGQMLIS TEVKFYNCSV
     HQLCLSCVNS AFRCHWCKYR NLCTHDPSSC SFQEGRVNAS EDCPQLVRSE EILIPAGEVK
     PITLKAKNLP QPQSGQRGYE CVLHIQGVSH RVTALRFNSS SVQCQNSSYL YEGMKISELP
     VDFSVVWNGN FIIDNPENIK VHLYKCAAQR DSCGMCLKAE RKFQCGWCSG EGRCTLRHHC
     PPINPYTTRW LNLSSKNVKC TNPRITEVTP VAGPPEGGTR VTIHGTNLGL AFSDMVGNVE
     VAGVRCTPVE DGYIIAEQIV CEMDMAHADS MPGPVQLCVG ECKPELRARS SQLYSFVTPT
     VTGLSPRRGP ESGGTKVTIM GENLGAGSSV NVKFGNQTCE FFGRTKTEIV CYSAPSLSGV
     GPVQISVSVD RAQIRESLTF EYTEDPTVQR IEPDWSIASG HTPLMVTGTN LDVVQEPRIR
     VKYAGRESVN VCKVLNTTSM SCFAPSLMAE YHPGLDTVKH ADEFGFIFNN VQALLVYNNT
     NLLYYPNPYF EPLSTTGILE QKPGSPIILK GRNLVPPASG GVKLNYTVLI GETPCSVTVS
     ESQLLCEPPN LTGQYKVMVQ VGGLHVSPGA VHIMSDSLLT LPAIVSIAAG GGLLLIIVIL
     VLIAYKRKSR ENDLTLKRLQ MQMDNLESRV ALECKEAFAE LQTDINELTS DLDRAGIPYL
     DYRTYAMRVL FPGIEDHPVL RELEVSGNGQ QNVEKALKLF GQLINNKVFL LTFIRTLEMQ
     RSFSMRDRGN VASLIMTALQ GRLEYATDVL KHLLSDLIDR NLESKNHPKL LLRRTESVAE
     KMLTNWFAFL LHKFLKECAG EPLFMLYCAI KQQMEKGPID AITGEARYSL SEDKLIRQQI
     EYKTLILNCV NPDNENSPEI PVKVLNCDTI TQVKEKILDA VYKNMPYSQR PRAVDMDLEW
     RQGRMARVVL QDEDITTKIE NDWKRLNTLM HYQVSDRCVV ALVPKQTSSY NIPSSASISR
     TSISRYDSSF RYTGSPDSLR SRAPMITPDL ESGVKVWHLV KNHEHGDQKE GDRGSKMVSE
     IYLTRLLATK GTLQKFVDDL FETLFSTVHR GSTLPLAIKY MFDFLDEQAD KHGIHDTDVR
     HTWKSNCLPL RFWVNVIKNP QFVFDIHKSS ITDACLSVVA QTFMDSCSTS EHRLGKDSPS
     NKLLYAKDIP NYKSWVERYY ADINRLPAIS DQDMNAYLAE QARLHSTEFN MLSALNEIYY
     YVSKYSEEIT AALDQDEQAR KQRLAYKVEQ LISAMSFES
//

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