ID   A0A3B4F6W4_9CICH        Unreviewed;       963 AA.
AC   A0A3B4F6W4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Huntingtin-interacting protein 1-related protein-like {ECO:0000313|Ensembl:ENSPNYP00000005354.1};
GN   Name=HIP1R {ECO:0000313|Ensembl:ENSPNYP00000005354.1};
OS   Pundamilia nyererei.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX   NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000005354.1, ECO:0000313|Proteomes:UP000261460};
RN   [1] {ECO:0000313|Ensembl:ENSPNYP00000005354.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SLA2 family.
CC       {ECO:0000256|ARBA:ARBA00010135}.
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DR   AlphaFoldDB; A0A3B4F6W4; -.
DR   STRING; 303518.ENSPNYP00000005354; -.
DR   Ensembl; ENSPNYT00000005495.1; ENSPNYP00000005354.1; ENSPNYG00000003944.1.
DR   GeneTree; ENSGT00940000153594; -.
DR   Proteomes; UP000261460; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 6.10.250.920; -; 1.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR032422; HIP1_clath-bd.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR030224; Sla2_fam.
DR   PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR   Pfam; PF07651; ANTH; 2.
DR   Pfam; PF16515; HIP1_clath_bdg; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF109885; I/LWEQ domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   DOMAIN          1..124
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   DOMAIN          677..909
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   REGION          230..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          909..931
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          285..312
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          868..904
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   963 AA;  108277 MW;  C1706FD44800E963 CRC64;
     SKAVTTAETP PKDKHVRNII MGTHKEGGAT AFWSYVLNLP LSSNSIVSWK FCYLVHKILR
     DGHRNVSSVF CISFTLYSPA LRLVICNLLC LFDVQHKVIP GNLEASDETL EKEAGSDMNK
     VEANQAKSTT PAGQCRLIPL IPLIQDCSFL YHFCVRLLFK LHSISPDVLL GHRDRFRDLF
     MSLTQFFDKA REMEFFKTFI QIPDLPDVSA PPNFLRAAAL AEYKKPVVVT PNEEHHEEEE
     DVEPQPEFRE ASQITPDSSV EQREMENDSL KRELDVLKPE LQIFKNEAQR CVTELKSQVN
     RLQAEVEEQR THKQMAMVEN EHLRMEVEAL RSTNVANIGA QIGFKEADGR AQAAELRFTQ
     LKERHAELVS SHADLMKKNT ETVKIMSSTK QEHDDLQRAK YQLETELENL RREKTQKLEI
     DRLKRDLEST RAELTQANNI LQSKEMSGTQ LNNTLAGLQV EKEGLLRMMR EQEAELKTLR
     QQTHLQQSSL EQERQRSSME LGGLHAQLQQ QASRESQLAQ KLQEEQFCLL QCAVVEAEGI
     ILDAVAKLDD PIHVRCISSP DYLVNRAEIT LNSIDKMQQS HLAYLGNSND ASGLLRAVTQ
     FSHLAADTIV NGSATSHSAP VDQANYLTDS CRDCANHCLH FLKDLKIQAS LQRADPSAIR
     YTVQRILAVG QDLRPKGHDV LKEELGSMVD KEMLATSSAI EEAVLRMDEI LSQAKKDNTG
     VKLEVNQNIL GSCSDLMKAV HMLVTAATDL QKDIVEGGRG AATVTEFYAK NSCWTEGLIS
     ASKAVGWGAT QNMDYQNLNT TEFLWHYCKH DVHAQKLSSV KADRNNKKLN TLQQASRHVN
     DMAAVVVTST KHGQQQISDH GLMDFSGMSL IKLKKEEMEA QVKVLQLESQ LEQERVRLGE
     LRKRHYELGV SGDEGDGVDS FPPPPPPALT EQHTKLSLKK TNIFTKSGNL LKNAVSASLT
     KVL
//