ID A0A3B4F702_9CICH Unreviewed; 1054 AA.
AC A0A3B4F702;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Integrin alpha-5-like {ECO:0000313|Ensembl:ENSPNYP00000005011.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000005011.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000005011.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3B4F702; -.
DR STRING; 303518.ENSPNYP00000005011; -.
DR Ensembl; ENSPNYT00000005136.1; ENSPNYP00000005011.1; ENSPNYG00000003577.1.
DR GeneTree; ENSGT00940000158061; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0001968; F:fibronectin binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0090245; P:axis elongation involved in somitogenesis; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl.
DR GO; GO:0001706; P:endoderm formation; IEA:Ensembl.
DR GO; GO:0085029; P:extracellular matrix assembly; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0070309; P:lens fiber cell morphogenesis; IEA:Ensembl.
DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
DR GO; GO:0032525; P:somite rostral/caudal axis specification; IEA:Ensembl.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF3; INTEGRIN ALPHA-5; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1004..1026
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 40..105
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 121..182
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 187..239
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 302..367
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 368..426
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 430..493
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 478..638
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 639..780
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 786..994
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1054 AA; 116725 MW; CFFF0E432300801B CRC64;
MGLVRFLTKT PGIVAFLARS FLCIIGLLLT LSKPACKAFN LDVENPAVYS GPNGSYFGYA
VDFYLSYSGS ASVLVGAPKA RTKQFNVTEG GSVFYCPWSS SQTDCHAIEF DLEGDRNVLL
NDTNYQADFK SHQWFGATVR SHGDTILACA PLYSWRTKED IPHSDATGSC YLSVENFTNF
VEYAPCRTEI SGPSGQGYCQ GGFSAEFTKD GKVVLGGPGS YFWQGQVISA AKEDIIRAYY
PGYFIQAVSG QIQTKQAHSL KDDSYQGYSV AAGEFSGDGV EDFVAGVPKG HMLYGSVRSL
NHHSHFGFHL SMGSYFGYAV ATTDINSDGM VDLLVGAPML MVRSSHGRLE EMGQVYVYLQ
RSPLKLESRL PLTGTQVFGR FGSTIAPLGD LNLDGFNDVA ISCPFGGEDQ QGLVYIYNGY
SEGLKQKPSQ VIRGQWAAGT IPASFGFALR GAKDLDMNGY PDLIVGAFGI NKAILYRSRP
IVNTSASLTV SPTMINPEEK NCILTTGNSS IPVSCVNLSF CISADGKHLP KNLDFQVEVQ
LDSHKHKQKG AVKRALFLDS QQPLLPMTVR LNHGERVCQH KRIYLRDEKE FRDKLSSIYV
ALNFSLDPKA AADSHGLRPI LNYQTTHVIE QKAQILLDCG EDNICVPDLK LAVSGDRKEV
YLGDDNSLTL TFNARNEGEG GAYEADLYVV LPPEADYIGI ARNNETLTQL TCSYETENQT
RYLSCDLGNP MKSGTNLWAG LRFTVPRLKD THKTIQFEAQ IRSKNENNSH SEVVASKLEV
IVKADVILQG VSRPDKVFFP PANWKLTKNY NVEVDVGPAV EHIYELVNNG PSRISHTLLE
LRCPFRVQGQ TLLYPLEFST EGPINCTADK NMNHRNLKLQ RSSTESPILA LKGHEHRLER
RDVHKNQLAH LTNLNCSTVD CWKVECNVGL LQKGTTAILK MRSRVWAETF TERAYKQYVL
ECLAEYRVKK MPYAIQPKLF PSGNKKVVTP VVWNKPDIEN SVPLWIIILA ILAGLLLLAL
LIYILYRLGF FKRSDPYGTA MEKAELKPQA ASEA
//
