ID A0A3B4F7A7_9CICH Unreviewed; 546 AA.
AC A0A3B4F7A7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Keratin, type II cytoskeletal 8-like {ECO:0000313|Ensembl:ENSPNYP00000005131.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000005131.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000005131.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A3B4F7A7; -.
DR Ensembl; ENSPNYT00000005261.1; ENSPNYP00000005131.1; ENSPNYG00000003902.1.
DR GeneTree; ENSGT00940000161090; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF21; KERATIN, TYPE II CYTOSKELETAL 7; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}.
FT DOMAIN 140..451
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 144..283
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 335..429
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 26..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 546 AA; 56917 MW; A2E5162D136F3E25 CRC64;
SDRLSGQAGG GGSFRMGGGG GGGGGRQSFS SRSVNLGGPM IMSSSTSMLR SGMASGGGGG
GGGGFSSYSF ASGGGSGFGA GGFGGGGGGG GGFGAGSFGG GGPGGFGSVP LITQVQVNQS
LLAPYNLEID PNIQTVRTQE KEQIKTLNNR FASFIDKVRF LEQQNKMLET KWSLLQEQTT
TRSNIDAMFE AYIANLRRQL DGLGNEKMKL ESELKNMQGL VEDFKNKYED EINKRAGVEN
EFVLLKKDVD GAYMNKIELE AKVDALQDEI NFLRAIYEAE LAELQGQIKD TSVIVEMDNS
RSLDMDAIVA EVKAQYEDIA NNSRAEAEKW YQSKFQEMQA NANQAGDDLR NTKSEIAELN
RMISRLQNEI EAVKGQRANL EAQIAEAEER GELAVKDAKV RIKDLEEALQ RAKQDMARQV
REYQELMNVK LALDIEIATY RKLLEGEESR IASGGGSATI HVQSTSSSFG GGRSGGGGGG
GGGFGGGFGG GFGGGMGGGG GGGFGGGMGG GGGMGYGGGI SVGGFGSGST SSISKTRVSS
SYSSRR
//
