ID A0A3B4F8G1_9CICH Unreviewed; 558 AA.
AC A0A3B4F8G1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Perforin-1-like {ECO:0000313|Ensembl:ENSPNYP00000005536.1};
OS Pundamilia nyererei.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Pundamilia.
OX NCBI_TaxID=303518 {ECO:0000313|Ensembl:ENSPNYP00000005536.1, ECO:0000313|Proteomes:UP000261460};
RN [1] {ECO:0000313|Ensembl:ENSPNYP00000005536.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3B4F8G1; -.
DR Ensembl; ENSPNYT00000005679.1; ENSPNYP00000005536.1; ENSPNYG00000004244.1.
DR GeneTree; ENSGT00530000063725; -.
DR Proteomes; UP000261460; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096:SF5; PERFORIN 1.3-RELATED; 1.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 25..362
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 385..501
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 558 AA; 61626 MW; 734FA1A827CD8C6B CRC64;
LLQTTSTASV TGTQVNRHVT SYKTNISSCE KAHFVPGYNL GGEGFDIVTM ERKGAYVIDT
ETWKIGNGNC RMYRNRYMNG EKQKVPVAVV DWRTLPKCSL KVSSVVYDSV ETLVSDSTSS
VSNNWTIGLD VPVGVGFGGS HSRDSTFAMK KSKEDRYTFL HHSINCHYYG YRLATSPPLS
QEFKSALDIP PYSSKTAPLY HNLIDTYGTH YITQVSLGGE IKATTAVKTC MATMNGLTDT
DVSDCLSVEA SASFANSASI NATIDHCQRK KNKLGSNQSF SSSFNERRTE VIGGDIDGGD
ILFAGQSDPS AYKNWLISLK SIPDVVQYNL KPLHTILPLN HPARAGLKQQ VEQYIKKNAV
LKKCSETCKI GHRSNARDPC ACVCNSNQNI KSNCCPAGKG LATLKVFKLY AKGLYGDKWT
ETDGSVEVTY GDQKKRTDII SNDDNPRWRE TFEFGTITIN MKNKLKFSVY DEDTYWNSDL
LGECSFDLRA GKVSGSCMLN HGTFFFSYIV ECAPSLSGNQ CQEYIPSAMS PSLAEVFHTR
NGVLLGKIGN KYEKPVNE
//
